用于控制和持续眼内给药的微针。

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Npg Asia Materials Pub Date : 2025-01-01 Epub Date: 2025-08-22 DOI:10.1038/s41427-025-00614-7
Junsang Lee, Jinheon Jeong, Van Phuc Nguyen, Seokkyoon Hong, Yannis M Paulus, Chi Hwan Lee
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引用次数: 0

摘要

微针(MNs)作为一种极具前景的微创给药技术,在眼部疾病的治疗中具有显著的优势。这些微型针头可以精确、局部地将药物直接输送到眼睛的特定组织,如角膜、巩膜、玻璃体或视网膜,同时最大限度地减少疼痛和不适。MNs可以由各种生物相容性材料制成,包括金属,硅和可生物降解聚合物,使其高度适应各种临床应用。MN设计的最新进展包括3D打印技术的集成,以创建高度定制的几何形状,以提高药物输送精度,使用智能材料,实现刺激响应和持续药物释放,以及结合不同聚合物的混合微针的开发,以提高机械强度和控制药物释放。这些创新已经确立了MNs作为传统方法(如滴眼液或玻璃体内注射)的优越替代方案,这些方法通常面临生物利用度和患者依从性有限的问题。本文综述了锰基眼部给药材料的研究现状,重点介绍了材料的发展、制备方法、药物释放机制和植入技术。本文还讨论了眼科学中MN技术的未来发展方向,强调了其改善复杂眼部疾病治疗结果的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Microneedles for controlled and sustained intraocular drug delivery.

Microneedles for controlled and sustained intraocular drug delivery.

Microneedles for controlled and sustained intraocular drug delivery.

Microneedles for controlled and sustained intraocular drug delivery.

Microneedles (MNs) have emerged as a promising technology for minimally invasive drug delivery, offering significant advantages in the treatment of ocular diseases. These miniaturized needles enable precise, localized drug delivery directly into specific tissues of the eye, such as the cornea, sclera, vitreous, or retina, while minimizing pain and discomfort. MNs can be fabricated from various biocompatible materials, including metals, silicon, and biodegradable polymers, making them highly adaptable to various clinical applications. Recent advancements in MN design include the integration of 3D printing technologies to create highly customized geometries for improved drug delivery precision, the use of smart materials that enable stimuli-responsive and sustained drug release, and the development of hybrid microneedles combining different polymers to enhance both mechanical strength and controlled drug release. These innovations have established MNs as a superior alternative to traditional methods like eye drops or intravitreal injections, which often face issues of limited bioavailability and patient compliance. This review summarizes the current state of research on MN-based ocular drug delivery, focusing on material developments, fabrication methods, drug release mechanisms, and implantation techniques. Future directions for MN technology in ophthalmology are also discussed, highlighting its potential to improve treatment outcomes for complex ocular diseases.

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来源期刊
Npg Asia Materials
Npg Asia Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
15.40
自引率
1.00%
发文量
87
审稿时长
2 months
期刊介绍: NPG Asia Materials is an open access, international journal that publishes peer-reviewed review and primary research articles in the field of materials sciences. The journal has a global outlook and reach, with a base in the Asia-Pacific region to reflect the significant and growing output of materials research from this area. The target audience for NPG Asia Materials is scientists and researchers involved in materials research, covering a wide range of disciplines including physical and chemical sciences, biotechnology, and nanotechnology. The journal particularly welcomes high-quality articles from rapidly advancing areas that bridge the gap between materials science and engineering, as well as the classical disciplines of physics, chemistry, and biology. NPG Asia Materials is abstracted/indexed in Journal Citation Reports/Science Edition Web of Knowledge, Google Scholar, Chemical Abstract Services, Scopus, Ulrichsweb (ProQuest), and Scirus.
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