结构灵活的（噻唑-2-基）Pd（烯丙基）Cl配合物用于芳基卤化物和酰胺的Suzuki-Miyaura交叉偶联。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-04 DOI:10.1021/acs.orglett.5c03118

Ruihong Wang, Xiaoxia Han, Jin Zhang*, Nana Chen, Li Sun, Gaopeng Zhang and Michal Szostak*,

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引用次数: 0

摘要

本研究引入了一类新的（NHC）Pd（烯丙基）Cl配合物，该配合物以噻唑-2-乙基为配体，与传统的咪唑-2-乙基相比，具有更强的空间和电子性能。这些空气稳定的Pd(II)-NHC催化剂在芳基溴和酰胺的化学选择性铃木-宫浦交联反应中表现出优异的反应活性。动力学研究表明，它们比传统的咪唑-2-吡啶基配合物具有更好的反应性。这些发现突出了噻唑基碳烯在推进pd催化交叉偶联反应中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Structurally Flexible (Thiazol-2-ylidene)Pd(Allyl)Cl Complexes for Suzuki–Miyaura Cross-Coupling of Aryl Halides and Amides

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Structurally Flexible (Thiazol-2-ylidene)Pd(Allyl)Cl Complexes for Suzuki–Miyaura Cross-Coupling of Aryl Halides and Amides

This study introduces a new class of (NHC)Pd(allyl)Cl complexes featuring thiazol-2-ylidene ligands, which exhibit enhanced steric and electronic properties compared to those of traditional imidazol-2-ylidenes. These air-stable Pd(II)–NHC catalysts demonstrate superior reactivity in chemoselective Suzuki–Miyaura cross-couplings of aryl bromides and amides. Kinetic studies reveal their superior reactivity over traditional imidazol-2-ylidene-based complexes. The findings highlight the potential of thiazole-based carbenes in advancing Pd-catalyzed cross-coupling reactions.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.