Morgan E Heber, Jeremy Hill, Janice M Massey, Vern C Juel, Shruti M Raja, Yuebing Li, Donald B Sanders
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Sensitivity of Repetitive Nerve Stimulation Performed in Early and Later Stages of Myasthenia Gravis.
Introduction/aims: Repetitive nerve stimulation (RNS) is a valuable tool in the diagnostic evaluation of myasthenia gravis (MG). However, there are conflicting reports of its sensitivity when performed ≤ 30 days from symptom onset. We aim to compare the sensitivity of RNS performed in the early versus later stages of MG.
Methods: Data from patients with MG who underwent RNS testing from 2017 to 2021 at Cleveland Clinic and from 1975 to 2001 at Duke University Medical Center were reviewed.
Results: A total of 525 patients with MG underwent RNS testing. RNS was performed ≤ 30 days after symptom onset in 32 patients (Early RNS) and in 493 patients > 30 days after onset (Late RNS). RNS was abnormal in 56.3% of patients in the Early RNS group and 59.4% of those in the Late RNS group (p = 0.72). There was no difference in RNS positivity rates for either group between the institutions.
Discussion: We found no significant difference in the sensitivity of RNS performed within or after 30 days from the onset of MG. Our findings support the use and value of RNS in the diagnostic evaluation of MG in patients presenting both early and late.
期刊介绍：
Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.
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