慢性应激、肠道微生物群和免疫:相互联系和对健康的影响。

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Hexiao Jia, Xiaodong Guo, Yihong Wei, Can Can, Na He, Hailei Zhang, Xinyu Yang, Hanyang Wu, Wancheng Liu, Daoxin Ma
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引用次数: 0

摘要

心理应激影响下丘脑-垂体-肾上腺(HPA)轴和交感-肾上腺-髓质(SAM)轴,直接影响免疫系统。应激不仅会影响造血干细胞的活性,还会增加炎症细胞的循环水平,从而可能加剧致病性。此外,压力影响激素释放、炎症和自主神经变化,这可以改变肠道微生物群的组成,间接改变免疫系统。本文旨在对应激、肠道菌群和造血之间关系的研究进行综述,以加深我们对三者之间复杂联系的理解,同时强调慢性疾病、全身性炎症和应激之间的双向影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic stress, gut microbiota, and immunity: interconnections and implications for health.

Psychological stress influences the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal -medullary (SAM) axes which directly impact the immune system. Stress not only affects hematopoietic stem cell activity but also increases the circulating levels of inflammatory cells, thereby potentially exacerbating pathogenic conditions. Moreover, stress affects hormone release, inflammation, and autonomic changes, which can modify the composition of the gut microbiota and indirectly alter the immune system. This review aims to summarize the research that demonstrates the relationships among stress, the gut microbiota, and hematopoiesis to increase our understanding of the intricate connections among them, while also highlighting the bidirectional influences among chronic diseases, systemic inflammation, and stress.

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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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