整合中性粒细胞、淋巴细胞和嗜酸性粒细胞:ci治疗的转移性黑色素瘤NLE指数的发展和验证。

IF 1.9 4区 医学 Q3 DERMATOLOGY
Fatma Pinar Açar, Caner Acar, Haydar Çağatay Yüksel, Gökhan Şahin, Bilge Bayir, Irem Özdemir, Tuğba Mermer, Burçak Karaca
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引用次数: 0

摘要

使用免疫检查点抑制剂(ICIs)治疗的转移性黑色素瘤患者的预后仍然存在差异。虽然中性粒细胞与淋巴细胞比率(NLR)和中性粒细胞与嗜酸性粒细胞比率(NER)是既定的标记,但我们假设中性粒细胞与淋巴细胞时间-嗜酸性粒细胞(NLE)指数可以提供更好的分层。我们分析了194例接受ICIs治疗的转移性黑色素瘤患者,分为训练组(n = 129)和验证组(n = 65)。最佳的NLE临界值将患者分为NLE低或NLE高。采用Kaplan-Meier、Cox回归和logistic回归评估生存结局和客观有效率(ORR)。比较NLE、NLR和NER的预测准确性。nle低患者的中位总生存期明显长于nle高患者(训练期:31.3个月vs 6.9个月;P = 0.011;验证期:33.5个月vs 9.1个月;P = 0.019)。低nle患者的中位无进展生存期也显著改善(训练:10.6个月vs 3.1个月;P = 0.029;验证:13.7个月vs 3.9个月;P = 0.012)。低nle组的ORR更高(训练组:46.0% vs 13.2%
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating neutrophils, lymphocytes and eosinophils: development and validation of the NLE Index in ICI-treated metastatic melanoma.

Prognosis for metastatic melanoma patients treated with immune checkpoint inhibitors (ICIs) remains heterogeneous. Although neutrophil-to-lymphocyte ratio (NLR) and neutrophil-to-eosinophil ratio (NER) are established markers, we hypothesized a neutrophil-to-lymphocyte-times-eosinophil (NLE) index would offer superior stratification. We analyzed 194 metastatic melanoma patients receiving ICIs, divided into training (n = 129) and validation (n = 65) cohorts. An optimal NLE cutoff categorized patients as NLE-low or NLE-high. Survival outcomes and objective response rate (ORR) were assessed using Kaplan-Meier, Cox regression, and logistic regression. Predictive accuracy of NLE, NLR, and NER was compared. Median overall survival was significantly longer in NLE-low versus NLE-high patients (training: 31.3 versus 6.9 months; P = 0.011; validation: 33.5 versus 9.1 months; P = 0.019). Median progression-free survival also improved significantly in NLE-low patients (training: 10.6 versus 3.1 months; P = 0.029; validation: 13.7 versus 3.9 months; P = 0.012). ORR was higher in NLE-low groups (training: 46.0% versus 13.2%; P < 0.001; validation: 43.6% versus 18.2%; P = 0.078). NLE demonstrated superior predictive accuracy compared with NLR and NER. The NLE index outperforms NLR and NER in predicting survival and response in metastatic melanoma patients treated with ICIs, providing a practical clinical tool.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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