NK细胞在癌症免疫治疗中的阴暗面。

IF 33.3 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-09-04 DOI:10.1158/2159-8290.cd-25-1042

Felipe Galvez-Cancino,Maria Armero,David R Withers,Paula Molero-Glez,Ana Melero,Belen Palencia,Ignacio Melero

{"title":"NK细胞在癌症免疫治疗中的阴暗面。","authors":"Felipe Galvez-Cancino,Maria Armero,David R Withers,Paula Molero-Glez,Ana Melero,Belen Palencia,Ignacio Melero","doi":"10.1158/2159-8290.cd-25-1042","DOIUrl":null,"url":null,"abstract":"NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.","PeriodicalId":9430,"journal":{"name":"Cancer discovery","volume":"1206 1","pages":"1777-1779"},"PeriodicalIF":33.3000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Dark Side of NK Cells in Cancer Immunotherapy.\",\"authors\":\"Felipe Galvez-Cancino,Maria Armero,David R Withers,Paula Molero-Glez,Ana Melero,Belen Palencia,Ignacio Melero\",\"doi\":\"10.1158/2159-8290.cd-25-1042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.\",\"PeriodicalId\":9430,\"journal\":{\"name\":\"Cancer discovery\",\"volume\":\"1206 1\",\"pages\":\"1777-1779\"},\"PeriodicalIF\":33.3000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer discovery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1158/2159-8290.cd-25-1042\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer discovery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1158/2159-8290.cd-25-1042","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

NK细胞是先天淋巴样细胞的一个子集，最初在小鼠和人类中发现，基于它们介导细胞毒性的能力。然而，最近在本期《癌症发现》杂志上发表的两项连续研究表明，NK细胞浸润并不总是有益的；相反，它可以通过免疫调节机制削弱免疫检查点封锁的功效。参见Pozniak et al., p. 1819的相关文章参见Song et al., p. 1835的相关文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Dark Side of NK Cells in Cancer Immunotherapy.

NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.