Hazem Koozi, Jonas Engström, Anders Larsson, Martin Spångfors, Hans Friberg, Attila Frigyesi
{"title":"血浆内皮抑素及其与重症监护新发急性肾损伤的关系。","authors":"Hazem Koozi, Jonas Engström, Anders Larsson, Martin Spångfors, Hans Friberg, Attila Frigyesi","doi":"10.1186/s40560-025-00820-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU admission, renal replacement therapy (RRT) within 7 days after ICU admission, and 30-day mortality.</p><p><strong>Methods: </strong>A retrospective multicentre study was performed with admissions to four ICUs. Blood samples were prospectively obtained at ICU admission and retrospectively analysed. The Kidney Disease: Improving Global Outcomes (KDIGO) criteria defined AKI. Endostatin at ICU admission was compared to and adjusted for creatinine, cystatin C, and the Simplified Acute Physiology Score 3 (SAPS-3). Regression models and mean areas under the receiver operating characteristic curves (AUCs) from repeated cross-validation were assessed.</p><p><strong>Results: </strong>In total, 4732 admissions were included. Endostatin was associated with new-onset AKI (OR 1.7, 95% CI 1.5 <math><mo>-</mo></math> 1.9), new-onset stage 3 AKI (OR 1.4, 95% CI 1.2 <math><mo>-</mo></math> 1.6), and RRT (OR 1.2, 95% CI 1.05 <math><mo>-</mo></math> 1.4) independently of creatinine, cystatin C, and SAPS-3. Endostatin was superior to creatinine and cystatin C in predicting new-onset AKI (mean AUC 0.67 vs. 0.63, p < 0.001). Adding endostatin to creatinine improved the prediction of new-onset AKI and new-onset stage 3 AKI, but not the need for RRT. Endostatin was not associated with 30-day mortality after adjusting for the SAPS-3 score.</p><p><strong>Conclusions: </strong>Endostatin at ICU admission is an independent predictor of new-onset AKI and may improve early AKI risk assessment in the ICU. However, its predictive value for RRT and 30-day mortality appears limited. External validation and studies on its clinical utility are warranted.</p>","PeriodicalId":16123,"journal":{"name":"Journal of Intensive Care","volume":"13 1","pages":"48"},"PeriodicalIF":4.7000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403487/pdf/","citationCount":"0","resultStr":"{\"title\":\"Plasma endostatin and its association with new-onset acute kidney injury in critical care.\",\"authors\":\"Hazem Koozi, Jonas Engström, Anders Larsson, Martin Spångfors, Hans Friberg, Attila Frigyesi\",\"doi\":\"10.1186/s40560-025-00820-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). 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Endostatin was associated with new-onset AKI (OR 1.7, 95% CI 1.5 <math><mo>-</mo></math> 1.9), new-onset stage 3 AKI (OR 1.4, 95% CI 1.2 <math><mo>-</mo></math> 1.6), and RRT (OR 1.2, 95% CI 1.05 <math><mo>-</mo></math> 1.4) independently of creatinine, cystatin C, and SAPS-3. Endostatin was superior to creatinine and cystatin C in predicting new-onset AKI (mean AUC 0.67 vs. 0.63, p < 0.001). Adding endostatin to creatinine improved the prediction of new-onset AKI and new-onset stage 3 AKI, but not the need for RRT. Endostatin was not associated with 30-day mortality after adjusting for the SAPS-3 score.</p><p><strong>Conclusions: </strong>Endostatin at ICU admission is an independent predictor of new-onset AKI and may improve early AKI risk assessment in the ICU. However, its predictive value for RRT and 30-day mortality appears limited. 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引用次数: 0
摘要
背景:内皮抑素是预测重症监护病房(ICU)急性肾损伤(AKI)和死亡率的一种有前景的生物标志物。我们研究了ICU入院时血浆内皮抑素水平作为ICU入院后48小时内新发AKI、ICU入院后7天内肾脏替代治疗(RRT)和30天死亡率的预测因子。方法:对4例icu患者进行回顾性多中心研究。在ICU入院时前瞻性采集血样并进行回顾性分析。肾脏疾病:改善全球预后(KDIGO)标准定义AKI。比较ICU入院时的内皮抑素,并根据肌酐、胱抑素C和简化急性生理评分3 (SAPS-3)进行调整。评估反复交叉验证的回归模型和受试者工作特征曲线下的平均面积。结果:共纳入4732例患者。内皮抑素与新发AKI (OR 1.7, 95% CI 1.5 - 1.9)、新发3期AKI (OR 1.4, 95% CI 1.2 - 1.6)和RRT (OR 1.2, 95% CI 1.05 - 1.4)相关,与肌酐、胱抑素C和SAPS-3无关。内皮抑素在预测新发AKI方面优于肌酐和胱抑素C(平均AUC 0.67 vs 0.63, p)。结论:ICU入院时内皮抑素是新发AKI的独立预测因子,可改善ICU早期AKI风险评估。然而,其对RRT和30天死亡率的预测价值似乎有限。对其临床应用的外部验证和研究是必要的。
Plasma endostatin and its association with new-onset acute kidney injury in critical care.
Background: Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU admission, renal replacement therapy (RRT) within 7 days after ICU admission, and 30-day mortality.
Methods: A retrospective multicentre study was performed with admissions to four ICUs. Blood samples were prospectively obtained at ICU admission and retrospectively analysed. The Kidney Disease: Improving Global Outcomes (KDIGO) criteria defined AKI. Endostatin at ICU admission was compared to and adjusted for creatinine, cystatin C, and the Simplified Acute Physiology Score 3 (SAPS-3). Regression models and mean areas under the receiver operating characteristic curves (AUCs) from repeated cross-validation were assessed.
Results: In total, 4732 admissions were included. Endostatin was associated with new-onset AKI (OR 1.7, 95% CI 1.5 1.9), new-onset stage 3 AKI (OR 1.4, 95% CI 1.2 1.6), and RRT (OR 1.2, 95% CI 1.05 1.4) independently of creatinine, cystatin C, and SAPS-3. Endostatin was superior to creatinine and cystatin C in predicting new-onset AKI (mean AUC 0.67 vs. 0.63, p < 0.001). Adding endostatin to creatinine improved the prediction of new-onset AKI and new-onset stage 3 AKI, but not the need for RRT. Endostatin was not associated with 30-day mortality after adjusting for the SAPS-3 score.
Conclusions: Endostatin at ICU admission is an independent predictor of new-onset AKI and may improve early AKI risk assessment in the ICU. However, its predictive value for RRT and 30-day mortality appears limited. External validation and studies on its clinical utility are warranted.
期刊介绍:
"Journal of Intensive Care" is an open access journal dedicated to the comprehensive coverage of intensive care medicine, providing a platform for the latest research and clinical insights in this critical field. The journal covers a wide range of topics, including intensive and critical care, trauma and surgical intensive care, pediatric intensive care, acute and emergency medicine, perioperative medicine, resuscitation, infection control, and organ dysfunction.
Recognizing the importance of cultural diversity in healthcare practices, "Journal of Intensive Care" also encourages submissions that explore and discuss the cultural aspects of intensive care, aiming to promote a more inclusive and culturally sensitive approach to patient care. By fostering a global exchange of knowledge and expertise, the journal contributes to the continuous improvement of intensive care practices worldwide.