1990-2021年老年人急性戊型肝炎全球趋势和跨国不平等:一项综合分析

IF 4.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Deliang Huang, Jinyan Jiang, Jinghan Peng, Zhibin Zhu, Yuanyuan Chen, Siyu Zhang, Huiyi Lai, Hong Yu, Qi Zhao, Yanna Wu, Yanping Chen, Jun Chen
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引用次数: 0

摘要

背景和目的:老年人急性戊型肝炎(AHE)可导致包括肝功能衰竭和死亡在内的严重并发症,但其流行病学特征仍不明确。本研究旨在评估过去30年老年人AHE负担、趋势和健康不平等,并进一步预测其到2030年的变化。方法:老年人AHE数据来自《2021年全球疾病负担》。通过趋势、分解、跨国不平等和预测分析来分析AHE负担。结果:2021年,全球老年人AHE发病率和伤残调整生命年(DALYs)分别为1,130,013.35和20,084.77。尽管各国的发病率和伤残调整生命年存在显著差异,但从1990年到2021年,发病例数有所增加,年龄标准化率略有上升,而伤残调整生命年的数量和年龄标准化率呈下降趋势。分解分析显示,人口增长和老龄化是发病率变化的驱动因素,而流行病学变化在一定程度上抵消了人口增长驱动的DALYs增长。社会人口指数低的国家承担着不成比例的老年AHE负担,尽管不平等差距随着时间的推移已经缩小。值得注意的是,到2030年,事故病例和伤残补偿年的数量将继续增加。老年妇女的负担比男性更明显。结论:老年AHE的负担,作为一个主要的公共卫生问题,仍然是实质性的。虽然随着时间的推移,跨国不平等现象有所缓解,但社会人口指数较低的国家控制这一疾病的压力仍然很大。老年妇女AHE需要进一步关注。这强调了控制和管理老年人AHE所面临的重大挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global Trends and Cross-country Inequalities of Acute Hepatitis E in the Elderly, 1990-2021: A Comprehensive Analysis.

Background and aims: Acute hepatitis E (AHE) in the elderly can lead to severe complications including liver failure and mortality, yet the epidemiological landscape remains poorly characterized. This study aimed to assess the burden, trends, and health inequalities of AHE among the elderly over the past three decades, and to further predict its changes by 2030.

Methods: Data on AHE in the elderly were obtained from the Global Burden of Disease 2021. The burden of AHE was analyzed by trends, decomposition, cross-country inequalities, and predictive analysis.

Results: In 2021, the global incidence and Disability-Adjusted Life Years (DALYs) for AHE among the elderly were recorded as 1,130,013.35 and 20,084.77, respectively. Although there were significant differences in the incidence and DALYs across countries, the number of incident cases increased from 1990 to 2021, with a slight rise in age-standardized rates, while the number and age-standardized rate of DALYs showed a declining trend. Decomposition analysis revealed that population growth and aging are the drivers of changes in incidence, while epidemiological changes somewhat offset the increases in DALYs driven by population growth. Low socio-demographic index countries bear a disproportionate burden of elderly AHE, although inequality gaps have narrowed over time. Notably, up to 2030, the number of incident cases and DALYs will continue increasing. The burden in elderly women was more pronounced than in men.

Conclusions: The burden of elderly AHE, as a major public health issue, remains substantial. While cross-country inequities have been alleviated over time, the pressure on lower socio-demographic index countries to control the disease remains high. AHE in elderly women requires further attention. This emphasizes the significant challenges faced in controlling and managing elderly AHE.

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来源期刊
Journal of Clinical and Translational Hepatology
Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.40
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2.80%
发文量
496
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