猪带绦虫感染后对再感染的免疫及定量剂量反应模型。

IF 3.2 2区 医学 Q1 PARASITOLOGY
Eloy Gonzales-Gustavson, Francesco Pizzitutti, Gabrielle Bonnet, Claudio Muro, Ricardo Gamboa, Javier A Bustos, Sarah Gabriël, William K Pan, Héctor H Garcia, Seth O'Neal
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引用次数: 0

摘要

猪带绦虫是一种人畜共患寄生虫,造成严重的健康和经济负担,其传播动态复杂,需要改进控制策略。本研究探讨了感染和再感染如何影响猪的囊肿发展,以及获得性免疫如何限制寄生虫负担。共从秘鲁北部的商业农场购买了116头猪,并在控制条件下饲养。其中,110头猪被分配到18个实验组,以评估单次和多次感染不同剂量的猪绦虫卵的影响,并根据感染剂量和年龄建立活囊肿数量的模型。从人类病例中收集的妊娠原蜥用于制备活卵池。通过食道导管口服感染,在最终感染10周后对猪进行尸检,以量化囊肿负荷。负二项回归模型评估感染剂量、既往感染、年龄和其他因素的影响。无论初始或再感染剂量如何,单次感染和再感染猪之间的囊肿计数均无显著差异,这突出表明感染可诱导强大的获得性免疫,从而防止后续感染。剂量-反应分析表明,囊肿负荷与卵子剂量呈幂相关。将单个和再感染猪的数据整合到统一的模型中,提高了预测精度。此外,纳入感染年龄使我们能够模拟获得性和先天免疫的综合影响,反映易感性随时间的变化。这些发现表明,单次接触猪绦虫卵可以在猪体内产生强大的保护性免疫。由此产生的定量模型,基于剂量和年龄预测可存活的囊肿数量,为将免疫动力学整合到传播模型中提供了有价值的见解,支持开发更有效的控制螺旋体的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunity against reinfection in pigs following Taenia solium infection and a quantitative dose-response model.

Taenia solium is a zoonotic parasite causing significant health and economic burdens, with complex transmission dynamics that demand improved control strategies. This study examines how infection and reinfection affect cyst development in pigs and how acquired immunity constrains parasite burden. A total of 116 pigs were purchased from commercial farms in northern Peru and housed under controlled conditions. Of these, 110 pigs were allocated to 18 experimental groups to evaluate the impact of single and repeated infections with varying doses of T. solium eggs and to model the number of live cysts produced based on dose and age at infection. Gravid proglottids collected from human cases were used to prepare viable egg pools. Infections were administered orally via esophageal catheterization, and pigs were necropsied 10 weeks after the final infection to quantify cyst burden. A negative binomial regression model assessed the influence of infection dose, prior infection, age, and other factors. No significant differences in cyst counts were found between singly infected and reinfected pigs, regardless of initial or reinfection doses, highlighting that infection induces strong acquired immunity that prevents subsequent infections. A dose-response analysis indicated that cyst burden follows a power relationship with egg dose. Integrating data from both single and reinfected pigs into a unified model improved prediction precision. Furthermore, incorporating age at infection allowed us to model the combined effects of acquired and innate immunity, reflecting changes in susceptibility over time. These findings demonstrate that a single exposure to T. solium eggs can generate robust protective immunity in pigs. The resulting quantitative model, predicting viable cyst counts based on dose and age, offers valuable insights for integrating immunity dynamics into transmission models, supporting the development of more effective strategies for controlling T. solium.

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来源期刊
CiteScore
8.40
自引率
2.50%
发文量
76
审稿时长
23 days
期刊介绍: International Journal for Parasitology offers authors the option to sponsor nonsubscriber access to their articles on Elsevier electronic publishing platforms. For more information please view our Sponsored Articles page. The International Journal for Parasitology publishes the results of original research in all aspects of basic and applied parasitology, including all the fields covered by its Specialist Editors, and ranging from parasites and host-parasite relationships of intrinsic biological interest to those of social and economic importance in human and veterinary medicine and agriculture.
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