{"title":"回顾PARTNER 3试验：5年血流动力学结果是否足以解决低危主动脉狭窄的争论？","authors":"Pradeep Narayan","doi":"10.1007/s12055-025-02040-4","DOIUrl":null,"url":null,"abstract":"<p><p>This review revisits the 5-year echocardiographic findings from the PARTNER 3 trial, which assessed valve performance in low-surgical-risk patients undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). While TAVR demonstrated early hemodynamic advantages, including more favourable right ventricular-pulmonary artery coupling and lower valvulo-arterial impedance, these benefits did not consistently translate into superior long-term outcomes. Emerging data from companion publications highlight a potential late mortality in the TAVR group, despite comparable early results. In younger, low-risk patients, long-term survival, not just early hemodynamic metrics, should remain the primary consideration when guiding treatment decisions.</p>","PeriodicalId":13285,"journal":{"name":"Indian Journal of Thoracic and Cardiovascular Surgery","volume":"41 9","pages":"1255-1257"},"PeriodicalIF":0.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373580/pdf/","citationCount":"0","resultStr":"{\"title\":\"Revisiting the PARTNER 3 trial: are 5-year hemodynamic findings enough to settle the debate in low-risk aortic stenosis?\",\"authors\":\"Pradeep Narayan\",\"doi\":\"10.1007/s12055-025-02040-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This review revisits the 5-year echocardiographic findings from the PARTNER 3 trial, which assessed valve performance in low-surgical-risk patients undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). While TAVR demonstrated early hemodynamic advantages, including more favourable right ventricular-pulmonary artery coupling and lower valvulo-arterial impedance, these benefits did not consistently translate into superior long-term outcomes. Emerging data from companion publications highlight a potential late mortality in the TAVR group, despite comparable early results. In younger, low-risk patients, long-term survival, not just early hemodynamic metrics, should remain the primary consideration when guiding treatment decisions.</p>\",\"PeriodicalId\":13285,\"journal\":{\"name\":\"Indian Journal of Thoracic and Cardiovascular Surgery\",\"volume\":\"41 9\",\"pages\":\"1255-1257\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12373580/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Thoracic and Cardiovascular Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12055-025-02040-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12055-025-02040-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/6 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Revisiting the PARTNER 3 trial: are 5-year hemodynamic findings enough to settle the debate in low-risk aortic stenosis?
This review revisits the 5-year echocardiographic findings from the PARTNER 3 trial, which assessed valve performance in low-surgical-risk patients undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). While TAVR demonstrated early hemodynamic advantages, including more favourable right ventricular-pulmonary artery coupling and lower valvulo-arterial impedance, these benefits did not consistently translate into superior long-term outcomes. Emerging data from companion publications highlight a potential late mortality in the TAVR group, despite comparable early results. In younger, low-risk patients, long-term survival, not just early hemodynamic metrics, should remain the primary consideration when guiding treatment decisions.
期刊介绍：
The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.
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