{"title":"I-II期子宫内膜癌术后复发预测因素：一项回顾性观察性研究。","authors":"Yushan Li, Hongli Wang, Shuyun Zhao","doi":"10.1080/14796694.2025.2546281","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment.</p><p><strong>Methods: </strong>130 stage I-II endometrioid carcinoma patients receiving laparoscopic surgery in Jincheng People's Hospital from January 2019 to January 2022 were retrospectively selected and diagnosed via HE assay. Their clinic and histology characteristics were collected. Kaplan-Meier survival analysis was to analyze the effect of chemotherapy and radiotherapy on the survival rate of the recurrent patients. Multivariate analysis was to explore the factors affecting postoperative recurrence.</p><p><strong>Results: </strong>Diagnosis was confirmed by diagnostic curettage in 129 cases. In 130 patients, the invading of superficial myometrium and deep myometrium was more obvious. After chemotherapy and radiotherapy treatment, the 5-year survival rate was 78.46%, and it was different among two therapies; (<i>p</i> = 0.006). Pathological type, disease stage, histological grade and myometrial invasion were the risk factors for recurrence. No significant difference in endometrioid adenocarcinoma proportion between 50 years old and ≤50 years old; (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The Stage I-II endometrial cancer recurrence after laparoscopic surgery can be judged by pathological type, disease stage, histological grade and myometrial invasion, providing theoretical basis for disease treatment to reduce the recurrence and improve the prognosis.</p>","PeriodicalId":12672,"journal":{"name":"Future oncology","volume":" ","pages":"2867-2874"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439563/pdf/","citationCount":"0","resultStr":"{\"title\":\"Post-surgery recurrence predictors for stage I-II endometrial carcinoma: a retrospective observational study.\",\"authors\":\"Yushan Li, Hongli Wang, Shuyun Zhao\",\"doi\":\"10.1080/14796694.2025.2546281\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment.</p><p><strong>Methods: </strong>130 stage I-II endometrioid carcinoma patients receiving laparoscopic surgery in Jincheng People's Hospital from January 2019 to January 2022 were retrospectively selected and diagnosed via HE assay. Their clinic and histology characteristics were collected. Kaplan-Meier survival analysis was to analyze the effect of chemotherapy and radiotherapy on the survival rate of the recurrent patients. Multivariate analysis was to explore the factors affecting postoperative recurrence.</p><p><strong>Results: </strong>Diagnosis was confirmed by diagnostic curettage in 129 cases. In 130 patients, the invading of superficial myometrium and deep myometrium was more obvious. After chemotherapy and radiotherapy treatment, the 5-year survival rate was 78.46%, and it was different among two therapies; (<i>p</i> = 0.006). Pathological type, disease stage, histological grade and myometrial invasion were the risk factors for recurrence. No significant difference in endometrioid adenocarcinoma proportion between 50 years old and ≤50 years old; (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The Stage I-II endometrial cancer recurrence after laparoscopic surgery can be judged by pathological type, disease stage, histological grade and myometrial invasion, providing theoretical basis for disease treatment to reduce the recurrence and improve the prognosis.</p>\",\"PeriodicalId\":12672,\"journal\":{\"name\":\"Future oncology\",\"volume\":\" \",\"pages\":\"2867-2874\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439563/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14796694.2025.2546281\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14796694.2025.2546281","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Post-surgery recurrence predictors for stage I-II endometrial carcinoma: a retrospective observational study.
Purpose: A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment.
Methods: 130 stage I-II endometrioid carcinoma patients receiving laparoscopic surgery in Jincheng People's Hospital from January 2019 to January 2022 were retrospectively selected and diagnosed via HE assay. Their clinic and histology characteristics were collected. Kaplan-Meier survival analysis was to analyze the effect of chemotherapy and radiotherapy on the survival rate of the recurrent patients. Multivariate analysis was to explore the factors affecting postoperative recurrence.
Results: Diagnosis was confirmed by diagnostic curettage in 129 cases. In 130 patients, the invading of superficial myometrium and deep myometrium was more obvious. After chemotherapy and radiotherapy treatment, the 5-year survival rate was 78.46%, and it was different among two therapies; (p = 0.006). Pathological type, disease stage, histological grade and myometrial invasion were the risk factors for recurrence. No significant difference in endometrioid adenocarcinoma proportion between 50 years old and ≤50 years old; (p > 0.05).
Conclusion: The Stage I-II endometrial cancer recurrence after laparoscopic surgery can be judged by pathological type, disease stage, histological grade and myometrial invasion, providing theoretical basis for disease treatment to reduce the recurrence and improve the prognosis.
期刊介绍：
Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community.
The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.
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