用长轴向视场PET/CT和124I成像验证正电子寿命。

IF 3.2 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Lorenzo Mercolli, William M Steinberger, Narendra Rathod, Maurizio Conti, Paweł Moskal, Axel Rominger, Robert Seifert, Kuangyu Shi, Ewa Ł Stępień, Hasan Sari
{"title":"用长轴向视场PET/CT和124I成像验证正电子寿命。","authors":"Lorenzo Mercolli, William M Steinberger, Narendra Rathod, Maurizio Conti, Paweł Moskal, Axel Rominger, Robert Seifert, Kuangyu Shi, Ewa Ł Stępień, Hasan Sari","doi":"10.1186/s40658-025-00790-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner.</p><p><strong>Methods: </strong>We prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 and 1.44 MBq of <sup>124</sup>I. The samples were scanned in two different setups: once with a couple of centimeters between each sample (15 min scan time) and once with all samples taped together (40 min scan time). For each scan, we determine the oPs lifetime for the full samples and at the voxel level. The voxel sizes under consideration are 10.0<sup>3</sup> mm<sup>3</sup>, 7.1<sup>3</sup> mm<sup>3</sup> and 4.0<sup>3</sup> mm<sup>3</sup>.</p><p><strong>Results: </strong>Amberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are 2.52 ± 0.03 ns, 2.37 ± 0.03 ns, 2.27 ± 0.04 ns and 1.82 ± 0.02 ns, respectively. The voxel-wise oPs lifetime fits showed that even with 4.0<sup>3</sup> mm<sup>3</sup> voxels the samples are clearly distinguishable and a central voxels have good count statistics. However, the situation with the samples close together remains challenging with respect to the spatial distinction of regions with different oPs lifetimes.</p><p><strong>Conclusions: </strong>Our study shows that positronium lifetime imaging on a commercial LAFOV PET/CT is feasible using <sup>124</sup>I.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"80"},"PeriodicalIF":3.2000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379202/pdf/","citationCount":"0","resultStr":"{\"title\":\"Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and <sup>124</sup>I.\",\"authors\":\"Lorenzo Mercolli, William M Steinberger, Narendra Rathod, Maurizio Conti, Paweł Moskal, Axel Rominger, Robert Seifert, Kuangyu Shi, Ewa Ł Stępień, Hasan Sari\",\"doi\":\"10.1186/s40658-025-00790-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner.</p><p><strong>Methods: </strong>We prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 and 1.44 MBq of <sup>124</sup>I. The samples were scanned in two different setups: once with a couple of centimeters between each sample (15 min scan time) and once with all samples taped together (40 min scan time). For each scan, we determine the oPs lifetime for the full samples and at the voxel level. The voxel sizes under consideration are 10.0<sup>3</sup> mm<sup>3</sup>, 7.1<sup>3</sup> mm<sup>3</sup> and 4.0<sup>3</sup> mm<sup>3</sup>.</p><p><strong>Results: </strong>Amberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are 2.52 ± 0.03 ns, 2.37 ± 0.03 ns, 2.27 ± 0.04 ns and 1.82 ± 0.02 ns, respectively. The voxel-wise oPs lifetime fits showed that even with 4.0<sup>3</sup> mm<sup>3</sup> voxels the samples are clearly distinguishable and a central voxels have good count statistics. However, the situation with the samples close together remains challenging with respect to the spatial distinction of regions with different oPs lifetimes.</p><p><strong>Conclusions: </strong>Our study shows that positronium lifetime imaging on a commercial LAFOV PET/CT is feasible using <sup>124</sup>I.</p>\",\"PeriodicalId\":11559,\"journal\":{\"name\":\"EJNMMI Physics\",\"volume\":\"12 1\",\"pages\":\"80\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379202/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40658-025-00790-z\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40658-025-00790-z","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

摘要

目的:测量人体组织中正电子离子(oPs)的寿命,有可能为常规正电子发射断层扫描(PET)增加有关组织微环境的临床相关信息。通过幻影测量,我们使用商用长轴视场(LAFOV) PET扫描仪研究了oPs寿命的体素测量。方法:用Amberlite XAD4、多孔聚合物吸附剂和水的混合物制备4种样品,加入1.12 ~ 1.44 MBq的124I。样品在两种不同的设置中进行扫描:一次是每个样品之间几厘米(15分钟扫描时间),一次是所有样品粘在一起(40分钟扫描时间)。对于每次扫描,我们确定完整样本和体素级别的oPs寿命。考虑的体素尺寸分别为10.03 mm3、7.13 mm3和4.03 mm3。结果:Amberlite XAD4可制备具有不同oPs寿命的样品。经贝叶斯拟合,整个样品的oPs寿命分别为2.52±0.03 ns、2.37±0.03 ns、2.27±0.04 ns和1.82±0.02 ns。体素方面的oPs寿命拟合表明,即使在4.03 mm3体素的情况下,样本也可以清晰地区分,并且中心体素具有良好的计数统计。然而,对于具有不同oPs寿命的区域的空间差异,样品靠近的情况仍然具有挑战性。结论:我们的研究表明,使用124I在商用LAFOV PET/CT上进行正电子寿命成像是可行的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and <sup>124</sup>I.

Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and <sup>124</sup>I.

Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and <sup>124</sup>I.

Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT and 124I.

Purpose: Measuring the ortho-positronium (oPs) lifetime in human tissue bears the potential of adding clinically relevant information about the tissue microenvironment to conventional positron emission tomography (PET). Through phantom measurements, we investigate the voxel-wise measurement of oPs lifetime using a commercial long-axial field-of-view (LAFOV) PET scanner.

Methods: We prepared four samples with mixtures of Amberlite XAD4, a porous polymeric adsorbent, and water and added between 1.12 and 1.44 MBq of 124I. The samples were scanned in two different setups: once with a couple of centimeters between each sample (15 min scan time) and once with all samples taped together (40 min scan time). For each scan, we determine the oPs lifetime for the full samples and at the voxel level. The voxel sizes under consideration are 10.03 mm3, 7.13 mm3 and 4.03 mm3.

Results: Amberlite XAD4 allows the preparation of samples with distinct oPs lifetime. Using a Bayesian fitting procedure, the oPs lifetimes in the whole samples are 2.52 ± 0.03 ns, 2.37 ± 0.03 ns, 2.27 ± 0.04 ns and 1.82 ± 0.02 ns, respectively. The voxel-wise oPs lifetime fits showed that even with 4.03 mm3 voxels the samples are clearly distinguishable and a central voxels have good count statistics. However, the situation with the samples close together remains challenging with respect to the spatial distinction of regions with different oPs lifetimes.

Conclusions: Our study shows that positronium lifetime imaging on a commercial LAFOV PET/CT is feasible using 124I.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
EJNMMI Physics
EJNMMI Physics Physics and Astronomy-Radiation
CiteScore
6.70
自引率
10.00%
发文量
78
审稿时长
13 weeks
期刊介绍: EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信