用深度学习改变药物治疗:个性化医疗的未来。

IF 2.1 Q3 PHARMACOLOGY & PHARMACY
Drug Research Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI:10.1055/a-2682-5167
Altaf Osman Mulani, Minal Deshmukh, Vaishali Jadhav, Kalyani Chaudhari, Ammu Anna Mathew, Shweta Salunkhe
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引用次数: 0

摘要

个性化医疗代表了医疗保健的范式转变,旨在根据个体患者独特的遗传、环境和生活方式特征量身定制治疗策略。这种方法在提高治疗效果和减少药物不良反应方面具有巨大的潜力。随着人工智能的快速发展,深度学习已经成为药理学领域的一种变革性工具,可以对复杂的生物数据进行精确建模,并发现患者特定信息中的隐藏模式。本研究探讨了深度学习技术在优化个性化治疗策略中的应用,如卷积神经网络(cnn)、循环神经网络(rnn)、变压器架构和生成对抗网络(GANs)。利用包括电子健康记录(EHRs)、基因组序列和临床指标在内的多样化数据集,我们开发并训练了深度学习模型,用于药物反应预测、生物标志物识别和药物不良反应(ADR)预测等任务。在评估的模型中,基于transformer的架构表现出优异的性能,在药物反应预测任务中实现了91.2%的准确率和0.92的AUC-ROC。此外,与传统的统计方法相比,将深度学习模型集成到治疗流程中可以使药物-患者匹配效率提高20-30%。研究结果强调了人工智能系统在加强临床决策和实现精确药物治疗方面的潜力。然而,数据隐私、模型可解释性和法规遵从性等挑战仍然是广泛采用的关键障碍。该研究还探讨了未来的发展方向,包括可解释人工智能(XAI)和联邦学习的实施,以解决这些限制,并促进深度学习融入常规临床实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transforming Drug Therapy with Deep Learning: The Future of Personalized Medicine.

Personalized medicine represents a paradigm shift in healthcare, aiming to tailor treatment strategies to the unique genetic, environmental, and lifestyle characteristics of individual patients. This approach holds immense potential for improving therapeutic efficacy and minimizing adverse drug reactions. With the rapid advancement of artificial intelligence, deep learning has emerged as a transformative tool in pharmacology, enabling precise modeling of complex biological data and uncovering hidden patterns in patient-specific information. This study investigates the application of deep learning techniques - such as Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), Transformer architectures, and Generative Adversarial Networks (GANs) - in optimizing personalized treatment strategies. Using a diverse dataset comprising electronic health records (EHRs), genomic sequences, and clinical indicators, we developed and trained deep learning models for tasks including drug response prediction, biomarker identification, and adverse drug reaction (ADR) forecasting. Among the models evaluated, Transformer-based architectures demonstrated superior performance, achieving an accuracy of 91.2% and an AUC-ROC of 0.92 in drug response prediction tasks. Moreover, the integration of deep learning models into the treatment pipeline resulted in a 20-30% improvement in drug-patient matching efficiency compared to traditional statistical methods. The findings underscore the potential of AI-powered systems to enhance clinical decision-making and enable precision pharmacotherapy. However, challenges such as data privacy, model interpretability, and regulatory compliance remain critical barriers to widespread adoption. The study also explores future directions, including the implementation of explainable AI (XAI) and federated learning, to address these limitations and facilitate the integration of deep learning into routine clinical practice.

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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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