痛风炎症:耀斑治疗的遗传机制。

IF 4.3 2区 医学 Q1 RHEUMATOLOGY
Current opinion in rheumatology Pub Date : 2025-11-01 Epub Date: 2025-08-20 DOI:10.1097/BOR.0000000000001119
Daniel Lyth, Megan Leask
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引用次数: 0

摘要

综述的目的:本综述提供了痛风的遗传基础途径的证据,应该优先进行进一步的研究和治疗开发。最近的发现:最近的全基因组关联研究已经确定了痛风发病的分子机制,这些机制集中在细胞代谢、晶体吞噬和细胞因子信号传导上。总结:了解基因通路如何影响痛风发作;晶体形成、晶体沉积和随后的免疫反应以及痛风耀斑的炎症特征对于开发痛风的附加疗法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gouty inflammation: genetic mechanisms towards flare therapy.

Purpose of review: This review presents evidence for pathways that have genetic underpinnings in gout that should be prioritized for further study and therapeutic development.

Recent findings: Recent genome-wide association studies have identified molecular mechanisms in the pathogenesis of gout that converge on cell metabolism, phagocytosis of crystals and cytokine signalling.

Summary: Understanding how the gene pathways function to influence the gout flare; crystal formation, crystal deposition and the subsequent immune response and inflammation characteristic of the gout flare is critical to developing additional therapies in the gout repertoire.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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