{"title":"痛风炎症:耀斑治疗的遗传机制。","authors":"Daniel Lyth, Megan Leask","doi":"10.1097/BOR.0000000000001119","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>This review presents evidence for pathways that have genetic underpinnings in gout that should be prioritized for further study and therapeutic development.</p><p><strong>Recent findings: </strong>Recent genome-wide association studies have identified molecular mechanisms in the pathogenesis of gout that converge on cell metabolism, phagocytosis of crystals and cytokine signalling.</p><p><strong>Summary: </strong>Understanding how the gene pathways function to influence the gout flare; crystal formation, crystal deposition and the subsequent immune response and inflammation characteristic of the gout flare is critical to developing additional therapies in the gout repertoire.</p>","PeriodicalId":11145,"journal":{"name":"Current opinion in rheumatology","volume":" ","pages":"430-436"},"PeriodicalIF":4.3000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Gouty inflammation: genetic mechanisms towards flare therapy.\",\"authors\":\"Daniel Lyth, Megan Leask\",\"doi\":\"10.1097/BOR.0000000000001119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>This review presents evidence for pathways that have genetic underpinnings in gout that should be prioritized for further study and therapeutic development.</p><p><strong>Recent findings: </strong>Recent genome-wide association studies have identified molecular mechanisms in the pathogenesis of gout that converge on cell metabolism, phagocytosis of crystals and cytokine signalling.</p><p><strong>Summary: </strong>Understanding how the gene pathways function to influence the gout flare; crystal formation, crystal deposition and the subsequent immune response and inflammation characteristic of the gout flare is critical to developing additional therapies in the gout repertoire.</p>\",\"PeriodicalId\":11145,\"journal\":{\"name\":\"Current opinion in rheumatology\",\"volume\":\" \",\"pages\":\"430-436\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/BOR.0000000000001119\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/BOR.0000000000001119","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Gouty inflammation: genetic mechanisms towards flare therapy.
Purpose of review: This review presents evidence for pathways that have genetic underpinnings in gout that should be prioritized for further study and therapeutic development.
Recent findings: Recent genome-wide association studies have identified molecular mechanisms in the pathogenesis of gout that converge on cell metabolism, phagocytosis of crystals and cytokine signalling.
Summary: Understanding how the gene pathways function to influence the gout flare; crystal formation, crystal deposition and the subsequent immune response and inflammation characteristic of the gout flare is critical to developing additional therapies in the gout repertoire.
期刊介绍:
A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.