关于“老年患者静脉注射布洛芬的安全性和有效性：回顾性亚组分析”的致编辑信-重新定义静脉注射布洛芬在老年疼痛管理中的使用：安全性，分层和多药的见解。

IF 3.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Clinical therapeutics Pub Date : 2025-08-30 DOI:10.1016/j.clinthera.2025.08.005

Schawanya K Rattanapitoon, Nav La, Phornpitcha Pechdee, Nathkapach K Rattanapitoon

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引用次数: 0

摘要

我们赞扬Gan等人的回顾性亚组分析，因为它解决了老年药物治疗中一个至关重要的问题——平衡老年患者的镇痛疗效和安全性。尽管他们的研究结果加强了静脉注射布洛芬治疗急性术后疼痛的效用，但我们对患者选择、合并症风险概况和多药治疗，特别是在体弱或多病的老年人群中，提供了进一步的观点。这封信扩展了将这些发现转化为现实世界环境的实践和临床考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Letter to the Editor Regarding "The Safety and Efficacy of Intravenous Ibuprofen in Older Patients: A Retrospective Subgroup Analysis"-Reframing Intravenous Ibuprofen Use in Geriatric Pain Management: Insights on Safety, Stratification, and Polypharmacy.

We commend the retrospective subgroup analysis by Gan et al. for addressing a vital concern in geriatric pharmacotherapy-balancing analgesic efficacy with safety in older patients. Although their findings reinforce the utility of intravenous ibuprofen for acute postoperative pain, we offer further perspectives on patient selection, comorbid risk profiles, and polypharmacy, particularly in frail or polymorbid geriatric populations. This letter expands on practical and clinical considerations in translating these findings into real-world settings.

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来源期刊

Clinical therapeutics 医学-药学

CiteScore

6.00

自引率

3.10%

发文量

154

审稿时长

9 weeks

期刊介绍： Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.