孟鲁司特引起的急性脑病1例。

IF 1.5 4区 医学 Q4 CLINICAL NEUROLOGY
Clinical Neuropharmacology Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI:10.1097/WNF.0000000000000652
Rebecca Fetter, James Wyant
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引用次数: 0

摘要

孟鲁司特与神经精神不良事件相关,包括情绪障碍、自杀倾向和焦虑症。研究表明孟鲁司特与谵妄之间可能存在关联;然而,大多数研究都集中在儿童和青少年身上。病例报告:一名59岁女性因脊柱骨髓炎、腰肌脓肿、硬膜外脓肿和菌血症而入院。入院第19天,患者新发脑病,检查未发现明确病因。在住院的第41天,她停止了家庭剂量的孟鲁司特,在接下来的几天里,她的精神状态有所改善。尽管其他医疗因素持续波动,但这种认知能力的改善是持续的。讨论:可能有许多因素导致了该患者的脑病,但孟鲁司特停药与精神状态改善之间的时间关系提示该药物与其症状之间存在关联。结论:我们报告了一位住院的急性脑病患者,在停用孟鲁司特后病情好转。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Case of Acute Encephalopathy Associated With Montelukast.

Introduction: Montelukast has been associated with neuropsychiatric adverse events including mood disorders, suicidality, and anxiety disorders. Studies have shown a possible association between montelukast and delirium; however, most of this research has been focused on children and adolescents.

Case report: A 59-year-old female was admitted for management of spinal osteomyelitis, psoas abscess, epidural abscess, and bacteremia. On hospital day 19, she had new onset of encephalopathy, and workup revealed no clear etiology. On hospital day 41, her home dose of montelukast was stopped, and her mentation improved over the next several days. This improvement in cognition was sustained even though other medical factors continued to fluctuate.

Discussion: There were many factors that may have contributed to this patient's encephalopathy, but the temporal relationship between cessation of montelukast and improvement in her mentation suggests an association between this medication and her symptoms.

Conclusion: We present a hospitalized patient with acute encephalopathy, which resolved after discontinuing montelukast.

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来源期刊
Clinical Neuropharmacology
Clinical Neuropharmacology 医学-临床神经学
CiteScore
1.20
自引率
10.00%
发文量
63
审稿时长
6-12 weeks
期刊介绍: Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.
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