阿尔茨海默病脑脊液瘦素:与血浆水平和脑脊液淀粉样蛋白的关系

IF 3.7 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Elodie Bouaziz-Amar, Jeanne Neez, Fidaa Ibrahim, Matthieu Martinet, Claire Hourregue, Julien Dumurgier, Emmanuel Cognat, Francois Mouton-Liger, Agathe Vrillon, Jacques Hugon, Claire Paquet, Matthieu Lilamand
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引用次数: 0

摘要

目的:脑瘦素信号的失调有助于阿尔茨海默病(AD)的病理生理,但血浆瘦素可能不能准确反映中枢神经系统的活动。本研究检测了血浆和脑脊液(CSF)瘦素水平的相关性及其与β -淀粉样蛋白(Aβ)和tau生物标志物的关系。方法:对来自三级记忆诊所的认知障碍患者的数据进行横断面分析。所有患者均采用CSF AD生物标志物进行诊断。采用标准化免疫分析法测定CSF和血浆瘦素。研究血浆和脑脊液瘦素水平的相关性。比较AD生物标志物阳性(A+T+N+)和神经对照(A-T-N-)患者脑脊液瘦素水平。通过回归分析研究CSF瘦素与CSF淀粉样蛋白和tau生物标志物之间的关系,并调整年龄、性别、体重指数(BMI)和肾小球滤过率(eGFR)。结果:最终纳入140名参与者(年龄69.8岁[1.1],女性=47.4 %)。CSF和血浆瘦素高度相关(r=0.79, p=)结论:CSF瘦素水平与血浆瘦素密切相关,并且在AD生物标志物阳性的个体中降低。这表明血浆瘦素可能反映中枢瘦素活性。我们的研究结果支持瘦素信号和AD中淀粉样蛋白沉积之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebrospinal fluid leptin in Alzheimer's disease: relationship to plasma levels and to cerebrospinal amyloid.

Objectives: Dysregulation of brain leptin signaling contributes to Alzheimer's disease (AD) pathophysiology, but plasma leptin may not accurately reflect central nervous system activity. This study examined the correlation between plasma and cerebrospinal fluid (CSF) leptin levels and their relationship with beta-amyloid (Aβ) and tau biomarkers.

Methods: Cross-sectional analysis of data from cognitively impaired patients from a tertiary memory clinic. All the patients were diagnosed using CSF AD biomarkers. CSF and plasma leptin were measured using standardized immunoassays. The correlation between plasma and CSF leptin levels was studied. CSF leptin levels were compared between patients with positive AD biomarkers (A+T+N+) and neurological controls (A-T-N-). Regression analyses were performed to study the relationship between CSF leptin and CSF amyloid and tau biomarkers, with adjustment for age, gender, body mass index (BMI) and estimated glomerular filtration rate (eGFR).

Results: Finally, 140 participants were included (age 69.8 [1.1], females=47.4 %). CSF and plasma leptin were highly correlated (r=0.79, p=<0.0001). Individuals with AD CSF profile (A+T+N+) showed lower CSF leptin concentrations than their A-T-N- counterparts (74.7 [4.7] vs. 120.9 [11.9] ng/L, p<0.01) and CSF leptin remained associated with ATN profile and more specifically with the amyloid beta ratio after adjusting for confounding factors (β=-0.60, [0.73], p<0.01).

Conclusions: CSF leptin levels strongly correlate with plasma leptin and are reduced in individuals with AD biomarker positivity. This suggests plasma leptin may reflect central leptin activity. Our findings support a link between leptin signaling and amyloid deposition in AD.

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来源期刊
Clinical chemistry and laboratory medicine
Clinical chemistry and laboratory medicine 医学-医学实验技术
CiteScore
11.30
自引率
16.20%
发文量
306
审稿时长
3 months
期刊介绍: Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!
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