NLRP3在系统性红斑狼疮免疫细胞中的研究进展。

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Yifan Liu, Yuqun Wang, Xiaodong Wang, Yajing Liu, Yingliang Wang
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引用次数: 0

摘要

系统性红斑狼疮(SLE)是一种以广泛器官受累和自身抗体产生异常为特征的多方面自身免疫性疾病。其潜在机制与免疫系统功能障碍密切相关。免疫学研究的最新进展强调了NLRP3炎性小体的关键作用,它是先天免疫和适应性免疫的关键调节因子。这种分子复合物在SLE研究中引起了极大的关注,因为它可以通过调节关键的促炎细胞因子(包括IL-1β和IL-18)来驱动病理性炎症,从而使其成为SLE发病机制研究的关键焦点。在本文中,我们对NLRP3炎性囊泡的结构和功能特征进行了系统的研究,重点探讨了NLRP3炎性囊泡在SLE发展过程中与不同免疫细胞群相互作用的机制,发现其在不同免疫细胞中的功能失调共同促成了SLE的病理过程。此外,本文还讨论了针对NLRP3炎性囊泡的潜在治疗策略,为SLE的研究和治疗引入了新的概念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research progress of NLRP3 in immune cells of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) represents a multifaceted autoimmune disorder characterised by widespread organ involvement and abnormal autoantibody production. Its underlying mechanisms are closely related to immune system dysfunction. Recent advancements in immunological research have highlighted the pivotal role of the NLRP3 inflammasome, which acts as a key regulator of both innate and adaptive immunity. This molecular complex has attracted significant attention in SLE studies because it can drive pathological inflammation by modulating key pro-inflammatory cytokines, including IL-1β and IL-18, thereby establishing itself as a critical focus in the investigation of SLE pathogenesis.In this review, we conducted a systematic examination of the structural and functional features of NLRP3 inflammatory vesicles, focused on the mechanism of their interaction with different immune cell populations during the development of SLE, and found that their dysfunctions in different immune cells jointly contributed to the pathological process of SLE. Moreover, potential therapeutic strategies aimed at targeting NLRP3 inflammatory vesicles are discussed to introduce novel concepts to the research and treatment of SLE.

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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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