{"title":"乳酸化在脂质代谢和相关疾病中的作用。","authors":"Bing Zhao, Zhuoqing Lan, Caixia Li, Hao Wang","doi":"10.1038/s41420-025-02705-4","DOIUrl":null,"url":null,"abstract":"<p><p>Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism.</p>","PeriodicalId":9735,"journal":{"name":"Cell Death Discovery","volume":"11 1","pages":"401"},"PeriodicalIF":7.0000,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375023/pdf/","citationCount":"0","resultStr":"{\"title\":\"Roles of lactylation in lipid metabolism and related diseases.\",\"authors\":\"Bing Zhao, Zhuoqing Lan, Caixia Li, Hao Wang\",\"doi\":\"10.1038/s41420-025-02705-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism.</p>\",\"PeriodicalId\":9735,\"journal\":{\"name\":\"Cell Death Discovery\",\"volume\":\"11 1\",\"pages\":\"401\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375023/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Death Discovery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41420-025-02705-4\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Death Discovery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41420-025-02705-4","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Roles of lactylation in lipid metabolism and related diseases.
Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism.
期刊介绍：
Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary.
Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
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