{"title":"利钠肽受体家族在恶性肿瘤中的作用及临床价值。","authors":"Chuqi Quan, Weilin Shao, Yihao Yang, Qian Yao, Zuozhang Yang, Zhihong Yao","doi":"10.1038/s41420-025-02656-w","DOIUrl":null,"url":null,"abstract":"<p><p>The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.</p>","PeriodicalId":9735,"journal":{"name":"Cell Death Discovery","volume":"11 1","pages":"412"},"PeriodicalIF":7.0000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394403/pdf/","citationCount":"0","resultStr":"{\"title\":\"The role and clinical value of natriuretic peptide receptor family in malignant tumor.\",\"authors\":\"Chuqi Quan, Weilin Shao, Yihao Yang, Qian Yao, Zuozhang Yang, Zhihong Yao\",\"doi\":\"10.1038/s41420-025-02656-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.</p>\",\"PeriodicalId\":9735,\"journal\":{\"name\":\"Cell Death Discovery\",\"volume\":\"11 1\",\"pages\":\"412\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394403/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Death Discovery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41420-025-02656-w\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Death Discovery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41420-025-02656-w","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
The role and clinical value of natriuretic peptide receptor family in malignant tumor.
The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.
期刊介绍：
Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary.
Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
