靶向氧化还原生物学治疗的最新创新。

IF 7.7 2区医学 Q1 PHARMACOLOGY & PHARMACY

British Journal of Pharmacology Pub Date : 2025-08-21 DOI:10.1111/bph.70156

Miriam M Cortese-Krott, Jon M Fukuto, Amrita Ahluwalia

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引用次数: 0

摘要

氧化还原信号控制着关键的生理和病理过程，在不同的疾病背景下提供不同的治疗靶点。这篇社论介绍了《英国药理学杂志》的一期特刊，重点介绍了氧化还原生物学的最新进展，包括新的小分子、非规范的一氧化氮和硫化氢途径、表观遗传调节和免疫调节。总之，这些贡献说明了氧化还原靶向药理学的转化潜力，并概述了该领域未来的创新方向。

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Recent innovations in targeting redox biology for therapeutics.

Redox signalling governs key physiological and pathological processes, offering diverse therapeutic targets across disease contexts. This editorial introduces a special issue of the British Journal of Pharmacology highlighting recent advances in redox biology, including novel small molecules, non-canonical nitric oxide and hydrogen sulfide pathways, epigenetic modulation and immune regulation. Together, these contributions illustrate the translational potential of redox-targeted pharmacology and outline future directions for innovation in the field.

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来源期刊

British Journal of Pharmacology 医学-药学

CiteScore

15.40

自引率

12.30%

发文量

270

审稿时长

2.0 months

期刊介绍： The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.