Minshan Huang, Jonathan R Olsen, Stewart G Trost, Carlos Celis-Morales, Jill P Pell, Frederick K Ho
{"title":"体育活动、空气污染和事件长期状况：一项前瞻性队列研究。","authors":"Minshan Huang, Jonathan R Olsen, Stewart G Trost, Carlos Celis-Morales, Jill P Pell, Frederick K Ho","doi":"10.1186/s12916-025-04338-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Physical activity (PA) is consistently associated with lower risk of long-term conditions. Preliminary evidence suggested the associations could be modified by air pollution. This study aims to examine whether air pollution levels modify the associations of PA with all-cause mortality and incident cancer, major adverse cardiovascular events (MACE), type 2 diabetes, and chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>A total of 414,644 UK Biobank participants were included in the analyses. PA was self-reported and objectively measured using accelerometers. PA was self-reported with IPAQ and objectively measured using accelerometers. Annual PM<sub>2.5</sub>, PM<sub>10</sub>, and NO air pollutant concentrations in 2010 were measured using a European land use regression model. Cox proportional hazard models were used to examine the associations of PA and air pollution with health outcomes. Multiplicative and additive interactions were estimated.</p><p><strong>Results: </strong>During the study period from 2006 to 2022, 31,765 (7.7%) died, 70,299 (17.0%) had incident cancer, 25,130 (8.5%) had type 2 diabetes, 33,284 (8.0%) had MACE, and 18,844 (4.5%) had COPD. Lower PA was associated with higher risk of all health outcomes. Higher concentration of PM<sub>2.5</sub> was associated with all outcomes except for cancer. The associations of self-reported PA with mortality and cancer were stronger in areas with higher air pollution with significant additive and multiplicative interactions. There was no evidence of moderation for objectively measured PA.</p><p><strong>Conclusions: </strong>In the UK, air pollution should not be a factor inhibiting the promotion of PA.</p>","PeriodicalId":9188,"journal":{"name":"BMC Medicine","volume":"23 1","pages":"491"},"PeriodicalIF":8.3000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374305/pdf/","citationCount":"0","resultStr":"{\"title\":\"Physical activity, air pollution, and incident long-term conditions: a prospective cohort study.\",\"authors\":\"Minshan Huang, Jonathan R Olsen, Stewart G Trost, Carlos Celis-Morales, Jill P Pell, Frederick K Ho\",\"doi\":\"10.1186/s12916-025-04338-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Physical activity (PA) is consistently associated with lower risk of long-term conditions. Preliminary evidence suggested the associations could be modified by air pollution. This study aims to examine whether air pollution levels modify the associations of PA with all-cause mortality and incident cancer, major adverse cardiovascular events (MACE), type 2 diabetes, and chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>A total of 414,644 UK Biobank participants were included in the analyses. PA was self-reported and objectively measured using accelerometers. PA was self-reported with IPAQ and objectively measured using accelerometers. Annual PM<sub>2.5</sub>, PM<sub>10</sub>, and NO air pollutant concentrations in 2010 were measured using a European land use regression model. Cox proportional hazard models were used to examine the associations of PA and air pollution with health outcomes. Multiplicative and additive interactions were estimated.</p><p><strong>Results: </strong>During the study period from 2006 to 2022, 31,765 (7.7%) died, 70,299 (17.0%) had incident cancer, 25,130 (8.5%) had type 2 diabetes, 33,284 (8.0%) had MACE, and 18,844 (4.5%) had COPD. Lower PA was associated with higher risk of all health outcomes. Higher concentration of PM<sub>2.5</sub> was associated with all outcomes except for cancer. The associations of self-reported PA with mortality and cancer were stronger in areas with higher air pollution with significant additive and multiplicative interactions. There was no evidence of moderation for objectively measured PA.</p><p><strong>Conclusions: </strong>In the UK, air pollution should not be a factor inhibiting the promotion of PA.</p>\",\"PeriodicalId\":9188,\"journal\":{\"name\":\"BMC Medicine\",\"volume\":\"23 1\",\"pages\":\"491\"},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2025-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374305/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12916-025-04338-x\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12916-025-04338-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Physical activity, air pollution, and incident long-term conditions: a prospective cohort study.
Background: Physical activity (PA) is consistently associated with lower risk of long-term conditions. Preliminary evidence suggested the associations could be modified by air pollution. This study aims to examine whether air pollution levels modify the associations of PA with all-cause mortality and incident cancer, major adverse cardiovascular events (MACE), type 2 diabetes, and chronic obstructive pulmonary disease (COPD).
Methods: A total of 414,644 UK Biobank participants were included in the analyses. PA was self-reported and objectively measured using accelerometers. PA was self-reported with IPAQ and objectively measured using accelerometers. Annual PM2.5, PM10, and NO air pollutant concentrations in 2010 were measured using a European land use regression model. Cox proportional hazard models were used to examine the associations of PA and air pollution with health outcomes. Multiplicative and additive interactions were estimated.
Results: During the study period from 2006 to 2022, 31,765 (7.7%) died, 70,299 (17.0%) had incident cancer, 25,130 (8.5%) had type 2 diabetes, 33,284 (8.0%) had MACE, and 18,844 (4.5%) had COPD. Lower PA was associated with higher risk of all health outcomes. Higher concentration of PM2.5 was associated with all outcomes except for cancer. The associations of self-reported PA with mortality and cancer were stronger in areas with higher air pollution with significant additive and multiplicative interactions. There was no evidence of moderation for objectively measured PA.
Conclusions: In the UK, air pollution should not be a factor inhibiting the promotion of PA.
期刊介绍：
BMC Medicine is an open access, transparent peer-reviewed general medical journal. It is the flagship journal of the BMC series and publishes outstanding and influential research in various areas including clinical practice, translational medicine, medical and health advances, public health, global health, policy, and general topics of interest to the biomedical and sociomedical professional communities. In addition to research articles, the journal also publishes stimulating debates, reviews, unique forum articles, and concise tutorials. All articles published in BMC Medicine are included in various databases such as Biological Abstracts, BIOSIS, CAS, Citebase, Current contents, DOAJ, Embase, MEDLINE, PubMed, Science Citation Index Expanded, OAIster, SCImago, Scopus, SOCOLAR, and Zetoc.
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