鼻给药在偏头痛治疗和脑靶向治疗中的作用：来自台湾的见解。

IF 2 4区医学 Q3 PHARMACOLOGY & PHARMACY

Biopharmaceutics & Drug Disposition Pub Date : 2025-08-25 DOI:10.1002/bdd.70013

Lien-Chung Wei, Hsien-Jane Chiu

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引用次数: 0

摘要

这封信回应了最近关于脑靶向治疗鼻腔给药系统的综述。根据台湾一位精神科医生和偏头痛患者的第一手经验，本文讨论了在持续药物短缺的情况下使用鼻用制剂（如舒马曲坦鼻喷雾剂）的实际益处和挑战。虽然这些配方提供快速起效，但与味道和气味有关的问题可能会限制依从性。这封信强调了纳米载体等先进技术在改善鼻腔给药方面的潜力，并强调了以患者为中心的设计的必要性。信函最后提出了多样化给药方法以提高疗效和可及性的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Nasal Drug Delivery in Migraine Management and Brain-Targeted Therapy: Insights From Taiwan

This letter responds to a recent review on nasal drug delivery systems for brain-targeted therapy. Drawing on first hand experiences as a psychiatrist and migraine patient in Taiwan, the response discusses the practical benefits and challenges of using nasal formulations, such as sumatriptan nasal spray, during ongoing drug shortages. While these formulations offer rapid onset of action, issues related to taste and odor can limit adherence. The letter highlights the potential of advanced technologies like nanocarriers to improve nasal drug delivery and emphasizes the need for patient-centered designs. The correspondence concludes with recommendations for diversifying drug delivery approaches to enhance efficacy and accessibility.

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来源期刊

Biopharmaceutics & Drug Disposition 医学-药学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Biopharmaceutics & Drug Dispositionpublishes original review articles, short communications, and reports in biopharmaceutics, drug disposition, pharmacokinetics and pharmacodynamics, especially those that have a direct relation to the drug discovery/development and the therapeutic use of drugs. These includes: - animal and human pharmacological studies that focus on therapeutic response. pharmacodynamics, and toxicity related to plasma and tissue concentrations of drugs and their metabolites, - in vitro and in vivo drug absorption, distribution, metabolism, transport, and excretion studies that facilitate investigations related to the use of drugs in man - studies on membrane transport and enzymes, including their regulation and the impact of pharmacogenomics on drug absorption and disposition, - simulation and modeling in drug discovery and development - theoretical treatises - includes themed issues and reviews and exclude manuscripts on - bioavailability studies reporting only on simple PK parameters such as Cmax, tmax and t1/2 without mechanistic interpretation - analytical methods