利特莫韦在成人造血细胞移植受者体内的群体药动学分析。

IF 4.5 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-10-01 Epub Date: 2025-08-22 DOI:10.1128/aac.00697-25

Léna Royston, Carla Kunz, David Tonoli, Pierre Lescuyer, Dionysios Neofytos, Verena Gotta

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引用次数: 0

摘要

我们使用基于模型的药物计量学分析分析了先前报道的40例同种异体造血细胞移植（HCT）受者口服利替莫韦的血浆浓度测量。该分析强调，行业赞助的III期研究模型明显高估了观察到的利特莫韦浓度。与口服清除率（CL/F）增加相关的协变量可能有助于这一观察结果，包括：体重增加，年龄较小，HCT后早期使用。临床意义和机制解释相对较低的现实世界暴露仍有待阐明。

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Population pharmacokinetic analysis of letermovir in adult hematopoietic cell transplant recipients.

We analyzed previously reported oral letermovir plasma concentration measurements from 40 allogeneic hematopoietic cell transplant (HCT) recipients using model-based pharmacometrics analysis. This analysis highlighted that the industry-sponsored phase III study model significantly over-predicted observed letermovir concentrations. Covariates associated with increased oral clearance (CL/F), possibly contributing to this observation, included: higher weight, younger age, and early use after HCT. The clinical significance and mechanistic explanation of relatively lower real-world exposure remains to be elucidated.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.