Karin Berger, Bernhard Moertl, Michael von Bergwelt-Baildon, Dominik Obermüller, Dorota Pawlowska-Phelan, Martin Dreyling
{"title":"滤泡性淋巴瘤或弥漫性大b细胞淋巴瘤：基于德国流行病学和健康经济方面的人口分析。","authors":"Karin Berger, Bernhard Moertl, Michael von Bergwelt-Baildon, Dominik Obermüller, Dorota Pawlowska-Phelan, Martin Dreyling","doi":"10.1007/s00277-025-06592-8","DOIUrl":null,"url":null,"abstract":"<p><p>Contemporary information on epidemiology, healthcare resource utilization (HCRU), costs and clinical outcomes in routine care is essential for value-based decision-making. However, such information remains limited for follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) in Germany. This study addresses these gaps. This retrospective cross-sectional cost-of-illness study analyzed anonymized statutory health insurance claims data (2015-2020). FL Grade I-IIIa (ICD-10: C82.0-C82.3), DLBCL (ICD-10: C83.3) patients were identified via inpatient or outpatient ICD coding. Elixhauser and Charlson Comorbidity Indices were used to describe the general comorbidity burden. FL prevalence increased from 26 to 32 per 100,000 insured persons (n = 837 to 1,028), DLBCL prevalence rose from 37 to 45 per 100,000 (n = 1,205 to 1,437). Mean age (FL: 67.0 ± 13; DLBCL: 68.6 ± 13.6) and sex distribution (FL: 50% female; DLBCL: 44% female) remained stable 2015-2020. Mean Charlson Comorbidity Index 4.1 ± 2.4 (FL), 4.8 ± 2.7 (DLBCL), mean Elixhauser 5.2 ± 3.0 (FL), 6.1 ± 3.3 (DLBCL). Hospitalization rates: 64% of FL patients (2.0 ± 2.3 admissions, 21 ± 44.7 days/year); 78% of DLBCL patients (2.9 ± 3.1 admissions, 29 ± 47.5 days/year). Mean annual costs per patient in third-party payers perspective were €15,258 (FL), €23,455 (DLBCL). Post-SCT 12-month costs were €46,270 (FL), €56,558 (DLBCL) for autologous-SCT, and €161,662 for allogeneic-SCT (DLBCL only). Rising prevalence calls for ongoing real-world assessment of HCRU and costs. This study supplements limited evidence, highlighting significant economic impact. While health insurance data offer valuable insights, their lack of clinical details necessitates integration with other data sources. Several initiatives are building data spaces to enhance evidence generation; meanwhile, analyses based on single data sources remain valuable to inform practice and policy.</p>","PeriodicalId":8068,"journal":{"name":"Annals of Hematology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Follicular lymphoma or diffuse large B-cell lymphoma: a population based analysis of epidemiological and health economic aspects in Germany.\",\"authors\":\"Karin Berger, Bernhard Moertl, Michael von Bergwelt-Baildon, Dominik Obermüller, Dorota Pawlowska-Phelan, Martin Dreyling\",\"doi\":\"10.1007/s00277-025-06592-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Contemporary information on epidemiology, healthcare resource utilization (HCRU), costs and clinical outcomes in routine care is essential for value-based decision-making. However, such information remains limited for follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) in Germany. This study addresses these gaps. This retrospective cross-sectional cost-of-illness study analyzed anonymized statutory health insurance claims data (2015-2020). FL Grade I-IIIa (ICD-10: C82.0-C82.3), DLBCL (ICD-10: C83.3) patients were identified via inpatient or outpatient ICD coding. Elixhauser and Charlson Comorbidity Indices were used to describe the general comorbidity burden. FL prevalence increased from 26 to 32 per 100,000 insured persons (n = 837 to 1,028), DLBCL prevalence rose from 37 to 45 per 100,000 (n = 1,205 to 1,437). Mean age (FL: 67.0 ± 13; DLBCL: 68.6 ± 13.6) and sex distribution (FL: 50% female; DLBCL: 44% female) remained stable 2015-2020. Mean Charlson Comorbidity Index 4.1 ± 2.4 (FL), 4.8 ± 2.7 (DLBCL), mean Elixhauser 5.2 ± 3.0 (FL), 6.1 ± 3.3 (DLBCL). Hospitalization rates: 64% of FL patients (2.0 ± 2.3 admissions, 21 ± 44.7 days/year); 78% of DLBCL patients (2.9 ± 3.1 admissions, 29 ± 47.5 days/year). Mean annual costs per patient in third-party payers perspective were €15,258 (FL), €23,455 (DLBCL). Post-SCT 12-month costs were €46,270 (FL), €56,558 (DLBCL) for autologous-SCT, and €161,662 for allogeneic-SCT (DLBCL only). Rising prevalence calls for ongoing real-world assessment of HCRU and costs. This study supplements limited evidence, highlighting significant economic impact. While health insurance data offer valuable insights, their lack of clinical details necessitates integration with other data sources. Several initiatives are building data spaces to enhance evidence generation; meanwhile, analyses based on single data sources remain valuable to inform practice and policy.</p>\",\"PeriodicalId\":8068,\"journal\":{\"name\":\"Annals of Hematology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00277-025-06592-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00277-025-06592-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Follicular lymphoma or diffuse large B-cell lymphoma: a population based analysis of epidemiological and health economic aspects in Germany.
Contemporary information on epidemiology, healthcare resource utilization (HCRU), costs and clinical outcomes in routine care is essential for value-based decision-making. However, such information remains limited for follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) in Germany. This study addresses these gaps. This retrospective cross-sectional cost-of-illness study analyzed anonymized statutory health insurance claims data (2015-2020). FL Grade I-IIIa (ICD-10: C82.0-C82.3), DLBCL (ICD-10: C83.3) patients were identified via inpatient or outpatient ICD coding. Elixhauser and Charlson Comorbidity Indices were used to describe the general comorbidity burden. FL prevalence increased from 26 to 32 per 100,000 insured persons (n = 837 to 1,028), DLBCL prevalence rose from 37 to 45 per 100,000 (n = 1,205 to 1,437). Mean age (FL: 67.0 ± 13; DLBCL: 68.6 ± 13.6) and sex distribution (FL: 50% female; DLBCL: 44% female) remained stable 2015-2020. Mean Charlson Comorbidity Index 4.1 ± 2.4 (FL), 4.8 ± 2.7 (DLBCL), mean Elixhauser 5.2 ± 3.0 (FL), 6.1 ± 3.3 (DLBCL). Hospitalization rates: 64% of FL patients (2.0 ± 2.3 admissions, 21 ± 44.7 days/year); 78% of DLBCL patients (2.9 ± 3.1 admissions, 29 ± 47.5 days/year). Mean annual costs per patient in third-party payers perspective were €15,258 (FL), €23,455 (DLBCL). Post-SCT 12-month costs were €46,270 (FL), €56,558 (DLBCL) for autologous-SCT, and €161,662 for allogeneic-SCT (DLBCL only). Rising prevalence calls for ongoing real-world assessment of HCRU and costs. This study supplements limited evidence, highlighting significant economic impact. While health insurance data offer valuable insights, their lack of clinical details necessitates integration with other data sources. Several initiatives are building data spaces to enhance evidence generation; meanwhile, analyses based on single data sources remain valuable to inform practice and policy.
期刊介绍：
Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
