{"title":"部分实性腺癌肿瘤大小的影像学巩固对生存的影响——倾向评分匹配分析。","authors":"Haruaki Hino, Natsumi Maru, Takahiro Utsumi, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Katsuyasu Kouda, Tomohiro Murakawa","doi":"10.21873/anticanres.17739","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>Recent evidence indicates that the radiographical consolidation tumor size of part-solid adenocarcinomas does not have prognostic value unlike that of pure-solid adenocarcinomas. We analyzed the impact of consolidation tumor size on postoperative survival in patients with part-solid adenocarcinoma.</p><p><strong>Patients and methods: </strong>This retrospective study analyzed data of 375 patients with part-solid adenocarcinomas who underwent surgery at our Institute between 2006 and 2021. The consolidation-to-tumor ratio (CTR) was determined using preoperative computed tomography and the patients were grouped into groups with low (0-≤0.5, n=187) or high (>0.5 to <1, n=188) CTR. Clinical characteristics and survival were analyzed using propensity score-matching for radiographical consolidation tumor size.</p><p><strong>Results: </strong>A larger radiographical consolidation tumor size significantly correlated with higher CTR (r<sup>2</sup>=0.56, <i>p</i><0.0001) and larger pathological invasive size (r<sup>2</sup>=0.41, <i>p</i><0.0001). Male sex and high radiographical consolidation tumor size were significant negative risk factors for overall survival in the unmatched cohort. The 5-year overall survival rates in the low- and high-CTR groups were 95.2% <i>versus</i> 85.2% (<i>p</i>=0.008) in the unmatched cohort, and 93.0% <i>versus</i> 83.2% (<i>p</i>=0.10) in the matched cohort. Competing-risk analysis showed 5-year cumulative incidence of cancer-specific death were 0% [95% confidence interval (CI)=not estimable] and 5.57% (95% CI=2.10-11.70%) in the low- and high-CTR groups, respectively (<i>p</i>=0.01), in contrast, the corresponding rates of non-cancer-related death were 4.72% (95% CI=1.40-11.10%) and 9.44% (95% CI=4.50-16.50%), respectively (<i>p</i>=0.18). These results indicate that survival of patients with consolidation-dominant part-solid adenocarcinoma is poor due to a higher rate of lung cancer death.</p><p><strong>Conclusion: </strong>The radiographical consolidation tumor size may affect overall survival and possibly reflect tumor growth activity, being consistent with 8<sup>th</sup> edition of the TNM classification in that larger consolidation tumor size significantly correlates with poor survival.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 9","pages":"3795-3807"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Radiographical Consolidation of Tumor Size of Part-solid Adenocarcinomas on Survival - A Propensity Score-matching Analysis.\",\"authors\":\"Haruaki Hino, Natsumi Maru, Takahiro Utsumi, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Katsuyasu Kouda, Tomohiro Murakawa\",\"doi\":\"10.21873/anticanres.17739\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aim: </strong>Recent evidence indicates that the radiographical consolidation tumor size of part-solid adenocarcinomas does not have prognostic value unlike that of pure-solid adenocarcinomas. We analyzed the impact of consolidation tumor size on postoperative survival in patients with part-solid adenocarcinoma.</p><p><strong>Patients and methods: </strong>This retrospective study analyzed data of 375 patients with part-solid adenocarcinomas who underwent surgery at our Institute between 2006 and 2021. The consolidation-to-tumor ratio (CTR) was determined using preoperative computed tomography and the patients were grouped into groups with low (0-≤0.5, n=187) or high (>0.5 to <1, n=188) CTR. Clinical characteristics and survival were analyzed using propensity score-matching for radiographical consolidation tumor size.</p><p><strong>Results: </strong>A larger radiographical consolidation tumor size significantly correlated with higher CTR (r<sup>2</sup>=0.56, <i>p</i><0.0001) and larger pathological invasive size (r<sup>2</sup>=0.41, <i>p</i><0.0001). Male sex and high radiographical consolidation tumor size were significant negative risk factors for overall survival in the unmatched cohort. The 5-year overall survival rates in the low- and high-CTR groups were 95.2% <i>versus</i> 85.2% (<i>p</i>=0.008) in the unmatched cohort, and 93.0% <i>versus</i> 83.2% (<i>p</i>=0.10) in the matched cohort. Competing-risk analysis showed 5-year cumulative incidence of cancer-specific death were 0% [95% confidence interval (CI)=not estimable] and 5.57% (95% CI=2.10-11.70%) in the low- and high-CTR groups, respectively (<i>p</i>=0.01), in contrast, the corresponding rates of non-cancer-related death were 4.72% (95% CI=1.40-11.10%) and 9.44% (95% CI=4.50-16.50%), respectively (<i>p</i>=0.18). These results indicate that survival of patients with consolidation-dominant part-solid adenocarcinoma is poor due to a higher rate of lung cancer death.</p><p><strong>Conclusion: </strong>The radiographical consolidation tumor size may affect overall survival and possibly reflect tumor growth activity, being consistent with 8<sup>th</sup> edition of the TNM classification in that larger consolidation tumor size significantly correlates with poor survival.</p>\",\"PeriodicalId\":8072,\"journal\":{\"name\":\"Anticancer research\",\"volume\":\"45 9\",\"pages\":\"3795-3807\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anticancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21873/anticanres.17739\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anticancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/anticanres.17739","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Impact of Radiographical Consolidation of Tumor Size of Part-solid Adenocarcinomas on Survival - A Propensity Score-matching Analysis.
Background/aim: Recent evidence indicates that the radiographical consolidation tumor size of part-solid adenocarcinomas does not have prognostic value unlike that of pure-solid adenocarcinomas. We analyzed the impact of consolidation tumor size on postoperative survival in patients with part-solid adenocarcinoma.
Patients and methods: This retrospective study analyzed data of 375 patients with part-solid adenocarcinomas who underwent surgery at our Institute between 2006 and 2021. The consolidation-to-tumor ratio (CTR) was determined using preoperative computed tomography and the patients were grouped into groups with low (0-≤0.5, n=187) or high (>0.5 to <1, n=188) CTR. Clinical characteristics and survival were analyzed using propensity score-matching for radiographical consolidation tumor size.
Results: A larger radiographical consolidation tumor size significantly correlated with higher CTR (r2=0.56, p<0.0001) and larger pathological invasive size (r2=0.41, p<0.0001). Male sex and high radiographical consolidation tumor size were significant negative risk factors for overall survival in the unmatched cohort. The 5-year overall survival rates in the low- and high-CTR groups were 95.2% versus 85.2% (p=0.008) in the unmatched cohort, and 93.0% versus 83.2% (p=0.10) in the matched cohort. Competing-risk analysis showed 5-year cumulative incidence of cancer-specific death were 0% [95% confidence interval (CI)=not estimable] and 5.57% (95% CI=2.10-11.70%) in the low- and high-CTR groups, respectively (p=0.01), in contrast, the corresponding rates of non-cancer-related death were 4.72% (95% CI=1.40-11.10%) and 9.44% (95% CI=4.50-16.50%), respectively (p=0.18). These results indicate that survival of patients with consolidation-dominant part-solid adenocarcinoma is poor due to a higher rate of lung cancer death.
Conclusion: The radiographical consolidation tumor size may affect overall survival and possibly reflect tumor growth activity, being consistent with 8th edition of the TNM classification in that larger consolidation tumor size significantly correlates with poor survival.
期刊介绍：
ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed.
ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies).
Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
