Matti Eskelinen, Riika Koskela, Tuomas Selander, Kai Kaarniranta, Paula Ollonen, Maaret Eskelinen
{"title":"心理压力对乳腺疾病和乳腺癌患者预后的影响：一项对有乳腺癌症状患者的前瞻性25年随访研究","authors":"Matti Eskelinen, Riika Koskela, Tuomas Selander, Kai Kaarniranta, Paula Ollonen, Maaret Eskelinen","doi":"10.21873/anticanres.17741","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>This study evaluated whether a psychological inventory (Forsen inventory, FI) for measuring the severity of psychological stress (PS) could predict long-term outcomes in patients having breast carcinoma (BC) symptoms.</p><p><strong>Patients and methods: </strong>A total of 115 patients with BC symptoms completed the FI scale and associations between FI scale and long-term outcomes were analysed using survival models.</p><p><strong>Results: </strong>The FI scores correlated with Beck Depression Inventory (BDI) (<i>r</i>=0.678, <i>p</i><0.001), Montgomery-Asberg Depression Rating Scale (MADRS) (<i>r</i>=0.820, <i>p</i><0.001), and State-Trait Anxiety inventory (STAI) (<i>r</i>=0.556, <i>p</i><0.001) levels. In Cox regression models, higher FI scores predicted poorer 25-year relapse-free survival (RFS) in BC patients (HR=2.60, <i>p</i>=0.05) and poorer 25-year overall survival (OS) in patients with benign breast disease (BBD) (HR=7.79, <i>p</i>=0.05). Kaplan-Meier analysis showed significantly better 25-year RFS among BC patients with low FI scores (<14) compared to those with high scores (≥14) (58.3% <i>vs.</i> 30.0%, <i>p</i>=0.046), and higher 25-year OS in BBD patients with low FI scores (95.8% <i>vs.</i> 71.4%, <i>p</i>=0.022).</p><p><strong>Conclusion: </strong>The FI scale, though underutilized, effectively captures PS and significantly predicts long-term outcomes in patients with breast disease. These findings suggest that incorporating the FI into diagnostic evaluations could enhance risk stratification and management for women with BC symptoms.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 9","pages":"3817-3826"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Psychological Stress <i>Versus</i> Outcome in Patients With Breast Disease and Breast Cancer: A Prospective 25-year Follow-up Study in Patients With Breast Cancer Symptoms.\",\"authors\":\"Matti Eskelinen, Riika Koskela, Tuomas Selander, Kai Kaarniranta, Paula Ollonen, Maaret Eskelinen\",\"doi\":\"10.21873/anticanres.17741\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aim: </strong>This study evaluated whether a psychological inventory (Forsen inventory, FI) for measuring the severity of psychological stress (PS) could predict long-term outcomes in patients having breast carcinoma (BC) symptoms.</p><p><strong>Patients and methods: </strong>A total of 115 patients with BC symptoms completed the FI scale and associations between FI scale and long-term outcomes were analysed using survival models.</p><p><strong>Results: </strong>The FI scores correlated with Beck Depression Inventory (BDI) (<i>r</i>=0.678, <i>p</i><0.001), Montgomery-Asberg Depression Rating Scale (MADRS) (<i>r</i>=0.820, <i>p</i><0.001), and State-Trait Anxiety inventory (STAI) (<i>r</i>=0.556, <i>p</i><0.001) levels. In Cox regression models, higher FI scores predicted poorer 25-year relapse-free survival (RFS) in BC patients (HR=2.60, <i>p</i>=0.05) and poorer 25-year overall survival (OS) in patients with benign breast disease (BBD) (HR=7.79, <i>p</i>=0.05). Kaplan-Meier analysis showed significantly better 25-year RFS among BC patients with low FI scores (<14) compared to those with high scores (≥14) (58.3% <i>vs.</i> 30.0%, <i>p</i>=0.046), and higher 25-year OS in BBD patients with low FI scores (95.8% <i>vs.</i> 71.4%, <i>p</i>=0.022).</p><p><strong>Conclusion: </strong>The FI scale, though underutilized, effectively captures PS and significantly predicts long-term outcomes in patients with breast disease. These findings suggest that incorporating the FI into diagnostic evaluations could enhance risk stratification and management for women with BC symptoms.</p>\",\"PeriodicalId\":8072,\"journal\":{\"name\":\"Anticancer research\",\"volume\":\"45 9\",\"pages\":\"3817-3826\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anticancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21873/anticanres.17741\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anticancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/anticanres.17741","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Psychological Stress Versus Outcome in Patients With Breast Disease and Breast Cancer: A Prospective 25-year Follow-up Study in Patients With Breast Cancer Symptoms.
Background/aim: This study evaluated whether a psychological inventory (Forsen inventory, FI) for measuring the severity of psychological stress (PS) could predict long-term outcomes in patients having breast carcinoma (BC) symptoms.
Patients and methods: A total of 115 patients with BC symptoms completed the FI scale and associations between FI scale and long-term outcomes were analysed using survival models.
Results: The FI scores correlated with Beck Depression Inventory (BDI) (r=0.678, p<0.001), Montgomery-Asberg Depression Rating Scale (MADRS) (r=0.820, p<0.001), and State-Trait Anxiety inventory (STAI) (r=0.556, p<0.001) levels. In Cox regression models, higher FI scores predicted poorer 25-year relapse-free survival (RFS) in BC patients (HR=2.60, p=0.05) and poorer 25-year overall survival (OS) in patients with benign breast disease (BBD) (HR=7.79, p=0.05). Kaplan-Meier analysis showed significantly better 25-year RFS among BC patients with low FI scores (<14) compared to those with high scores (≥14) (58.3% vs. 30.0%, p=0.046), and higher 25-year OS in BBD patients with low FI scores (95.8% vs. 71.4%, p=0.022).
Conclusion: The FI scale, though underutilized, effectively captures PS and significantly predicts long-term outcomes in patients with breast disease. These findings suggest that incorporating the FI into diagnostic evaluations could enhance risk stratification and management for women with BC symptoms.
期刊介绍：
ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed.
ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies).
Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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