欧洲微循环阻力和绝对流量团队的基本原理和设计：欧洲工艺注册。

IF 3.5 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal Pub Date : 2025-08-27 DOI:10.1016/j.ahj.2025.08.018

Masahiro Hada MD, PhD , Carlos Collet MD, PhD , Tatyana Storozhenko MD, PhD , Daniel Munhoz MD, PhD , Adriaan Wilgenhof MD , Alejandro Gutiérrez-Barrios MD, PhD , Annemiek de Vos MD , Branko Beleslin MD, PhD , Colin Berry MD, PhD , Divaka Perera MD , Fernando Rivero MD , Frederic Bouisset MD, PhD , Giovanni Luigi De Maria MD, PhD , Grigoris Karamasis MD, PhD , Jacob Lønborg MD, PhD , Javier Escaned MD, PhD , Kazumasa Ikeda MD , Kevin Carson MD , Klio Konstantinou MBBS , Mark Mariathas BM , Bernard De Bruyne MD, PhD

{"title":"欧洲微循环阻力和绝对流量团队的基本原理和设计：欧洲工艺注册。","authors":"Masahiro Hada MD, PhD , Carlos Collet MD, PhD , Tatyana Storozhenko MD, PhD , Daniel Munhoz MD, PhD , Adriaan Wilgenhof MD , Alejandro Gutiérrez-Barrios MD, PhD , Annemiek de Vos MD , Branko Beleslin MD, PhD , Colin Berry MD, PhD , Divaka Perera MD , Fernando Rivero MD , Frederic Bouisset MD, PhD , Giovanni Luigi De Maria MD, PhD , Grigoris Karamasis MD, PhD , Jacob Lønborg MD, PhD , Javier Escaned MD, PhD , Kazumasa Ikeda MD , Kevin Carson MD , Klio Konstantinou MBBS , Mark Mariathas BM , Bernard De Bruyne MD, PhD","doi":"10.1016/j.ahj.2025.08.018","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Coronary microvascular dysfunction (CMD) is increasingly recognized as an important cause of anginal symptoms and poor outcomes. Angina with nonobstructive coronary arteries (ANOCA) is often related to CMD. While physiological assessment of microcirculatory function by coronary bolus thermodilution is widely practiced, more precise and reproducible methodology as well as systematic assessment are necessary. Recently, absolute flow measurements by coronary continuous thermodilution and the concept of Microvascular Resistance Reserve (MRR) have been introduced.</div></div><div><h3>Aim</h3><div>The European microCirculatory Resistance and Absolute Flow Team (EuroCRAFT) registry aims to compare major adverse cardiac and cerebrovascular events (MACCE)-rates in patients with and without CMD based on MRR at 1-year follow-up.</div></div><div><h3>Methods</h3><div>This prospective international, investigator-initiated, multicenter study is enrolling patients with stable chest pain suggestive of angina and nonobstructive epicardial coronary arteries on invasive coronary angiography, defined as fractional flow reserve >0.80. Patients will undergo coronary angiography and microvascular assessment using bolus and continuous thermodilution methods. The primary endpoint is to compare the rate of MACCE in patients with and without CMD assessed with MRR at 1 year. Based on the sample size estimation, 671 patients are initially planned for enrollment.</div><div>We hypothesize that coronary continuous thermodilution-derived MRR has superior prognostic value for MACCE at 1 year compared to bolus thermodilution-derived microvascular metrics.</div></div><div><h3>Results</h3><div>Study recruitment started in September 2022 and has been completed in May 2025, resulting in a total of 678 patients enrolled.</div></div>","PeriodicalId":7868,"journal":{"name":"American heart journal","volume":"291 ","pages":"Pages 136-143"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry\",\"authors\":\"Masahiro Hada MD, PhD , Carlos Collet MD, PhD , Tatyana Storozhenko MD, PhD , Daniel Munhoz MD, PhD , Adriaan Wilgenhof MD , Alejandro Gutiérrez-Barrios MD, PhD , Annemiek de Vos MD , Branko Beleslin MD, PhD , Colin Berry MD, PhD , Divaka Perera MD , Fernando Rivero MD , Frederic Bouisset MD, PhD , Giovanni Luigi De Maria MD, PhD , Grigoris Karamasis MD, PhD , Jacob Lønborg MD, PhD , Javier Escaned MD, PhD , Kazumasa Ikeda MD , Kevin Carson MD , Klio Konstantinou MBBS , Mark Mariathas BM , Bernard De Bruyne MD, PhD\",\"doi\":\"10.1016/j.ahj.2025.08.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Coronary microvascular dysfunction (CMD) is increasingly recognized as an important cause of anginal symptoms and poor outcomes. Angina with nonobstructive coronary arteries (ANOCA) is often related to CMD. While physiological assessment of microcirculatory function by coronary bolus thermodilution is widely practiced, more precise and reproducible methodology as well as systematic assessment are necessary. Recently, absolute flow measurements by coronary continuous thermodilution and the concept of Microvascular Resistance Reserve (MRR) have been introduced.</div></div><div><h3>Aim</h3><div>The European microCirculatory Resistance and Absolute Flow Team (EuroCRAFT) registry aims to compare major adverse cardiac and cerebrovascular events (MACCE)-rates in patients with and without CMD based on MRR at 1-year follow-up.</div></div><div><h3>Methods</h3><div>This prospective international, investigator-initiated, multicenter study is enrolling patients with stable chest pain suggestive of angina and nonobstructive epicardial coronary arteries on invasive coronary angiography, defined as fractional flow reserve >0.80. Patients will undergo coronary angiography and microvascular assessment using bolus and continuous thermodilution methods. The primary endpoint is to compare the rate of MACCE in patients with and without CMD assessed with MRR at 1 year. Based on the sample size estimation, 671 patients are initially planned for enrollment.</div><div>We hypothesize that coronary continuous thermodilution-derived MRR has superior prognostic value for MACCE at 1 year compared to bolus thermodilution-derived microvascular metrics.</div></div><div><h3>Results</h3><div>Study recruitment started in September 2022 and has been completed in May 2025, resulting in a total of 678 patients enrolled.</div></div>\",\"PeriodicalId\":7868,\"journal\":{\"name\":\"American heart journal\",\"volume\":\"291 \",\"pages\":\"Pages 136-143\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American heart journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002870325003187\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American heart journal","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002870325003187","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

摘要

导语：冠状动脉微血管功能障碍（CMD）越来越被认为是心绞痛症状和不良预后的重要原因。非阻塞性冠状动脉心绞痛（ANOCA）常与CMD有关。虽然通过冠状动脉热稀释法对微循环功能进行生理评估已被广泛应用，但更精确和可重复的方法以及系统的评估是必要的。近年来，冠状动脉连续热稀释法测量绝对血流和微血管阻力储备（MRR）的概念被引入。目的：欧洲微循环阻力和绝对血流小组（EuroCRAFT）注册旨在比较基于MRR的1年随访中有和无CMD患者的主要心脑血管不良事件（MACCE）发生率。方法：这项前瞻性的、研究者发起的、多中心的国际研究招募了有创冠状动脉造影显示有心绞痛和非阻塞性心外膜冠状动脉的稳定胸痛患者，定义为血流储备分数>0.80。患者将接受冠状动脉造影和微血管评估，使用大剂量和连续热稀释方法。主要终点是比较一年内MRR评估的有和无CMD患者的MACCE发生率。根据样本量估计，最初计划入组671例患者。我们假设冠状动脉连续热调节衍生的MRR与大剂量热调节衍生的微血管指标相比，在一年的MACCE中具有更好的预后价值。研究招募于2022年9月开始，于2025年5月完成，共有679名患者入组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry

Introduction

Coronary microvascular dysfunction (CMD) is increasingly recognized as an important cause of anginal symptoms and poor outcomes. Angina with nonobstructive coronary arteries (ANOCA) is often related to CMD. While physiological assessment of microcirculatory function by coronary bolus thermodilution is widely practiced, more precise and reproducible methodology as well as systematic assessment are necessary. Recently, absolute flow measurements by coronary continuous thermodilution and the concept of Microvascular Resistance Reserve (MRR) have been introduced.

Aim

The European microCirculatory Resistance and Absolute Flow Team (EuroCRAFT) registry aims to compare major adverse cardiac and cerebrovascular events (MACCE)-rates in patients with and without CMD based on MRR at 1-year follow-up.

Methods

This prospective international, investigator-initiated, multicenter study is enrolling patients with stable chest pain suggestive of angina and nonobstructive epicardial coronary arteries on invasive coronary angiography, defined as fractional flow reserve >0.80. Patients will undergo coronary angiography and microvascular assessment using bolus and continuous thermodilution methods. The primary endpoint is to compare the rate of MACCE in patients with and without CMD assessed with MRR at 1 year. Based on the sample size estimation, 671 patients are initially planned for enrollment.

We hypothesize that coronary continuous thermodilution-derived MRR has superior prognostic value for MACCE at 1 year compared to bolus thermodilution-derived microvascular metrics.

Results

Study recruitment started in September 2022 and has been completed in May 2025, resulting in a total of 678 patients enrolled.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.