液体营养饮料试验诱发与胃十二指肠症状相关的胃肌电异常。

IF 3.3 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Hassan Shaaban, Chris Varghese, Gabriel Schamberg, India Wallace, Mikaela Law, Nooriyah Poonawala, William Xu, Christopher N Andrews, Armen Gharibans, Jan Tack, Gregory O'Grady, Stefan Calder
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引用次数: 0

摘要

功能性消化不良、慢性恶心和呕吐综合征以及胃轻瘫等慢性胃十二指肠症状影响了全球10%以上的人口,并造成了重大的医疗负担。异常的胃肌电活动与症状发生之间的关系仍不完全明确。在这项研究中,我们使用无创体表胃测图(BSGM)和胃电测量系统(奥克兰,新西兰)评估了营养液体饮料试验(LNDT)引起的胃膨胀对健康志愿者胃肌电活动的影响。20名健康参与者(10名女性)接受了BSGM,空腹基线为30分钟,LNDT以30 mL/min的剂量给药,直到最大耐受,餐后4小时记录。使用混合模型分析胃节律指数(GA-RI)、主胃频率(PGF)和bmi调整振幅随时间的变化以及与症状的关系。在LNDT期间,PGF显著下降(2.7±0.2 vs.总体平均3.0±0.2 cycles/min, P < 0.001), GA-RI下降(β = -0.11, 95% CI -0.21至-0.002,P = 0.047),同时恶心评分增加。在餐后的第一个小时,腹胀、恶心和总体症状负担加重,GA-RI和PGF的持续降低与较高的症状评分相关。光谱分析显示短暂的异常在时间上与症状发生一致。这些发现表明,胃过度膨胀引起异常的胃肌电活动,与前肠症状密切相关,支持这些异常在神经性胃十二指肠疾病的病理生理学中的作用。体表胃测图与营养液体饮料试验发现,胃过度膨胀引起与前肠症状密切相关的心律失常,支持胃肌电功能紊乱在神经胃十二指肠疾病病理生理中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liquid nutrient drink testing induces gastric myoelectrical abnormalities that correlate with gastroduodenal symptoms.

Chronic gastroduodenal symptoms experienced in functional dyspepsia, chronic nausea and vomiting syndromes, and gastroparesis affect over 10% of the global population and impose a significant healthcare burden. The relationship between aberrant gastric myoelectrical activity and symptom genesis remains incompletely defined. In this study, we evaluated the effects of gastric distension induced by a liquid nutrient drink test (LNDT) on gastric myoelectrical activity in healthy volunteers using noninvasive body surface gastric mapping (BSGM) with the Gastric Alimetry system (Auckland, New Zealand). Twenty healthy participants (10 females) underwent BSGM with 30-min fasting baseline, LNDT with Ensure administered at 30 mL/min until maximal toleration, and 4-h postprandial recording. Gastric Alimetry Rhythm Index (GA-RI), principal gastric frequency (PGF), and BMI-adjusted amplitude were analyzed across time and in relation to symptoms using mixed models. During LNDT, PGF decreased significantly (2.7 ± 0.2 vs. an overall average 3.0 ± 0.2 cycles/min, P < 0.001) and GA-RI declined (β = -0.11, 95% CI -0.21 to -0.002, P = 0.047) with a concurrent increase in nausea ratings. In the first postprandial hour, bloating, nausea, and overall symptom burden were elevated, with sustained reductions in GA-RI and PGF correlating with higher symptom scores. Spectral analyses revealed transient abnormalities temporally aligned with symptom genesis. These findings indicate that excessive gastric distension provokes aberrant gastric myoelectrical activity that is closely associated with foregut symptoms, supporting the role of these abnormalities in the pathophysiology of neurogastroduodenal disorders.NEW & NOTEWORTHY Body surface gastric mapping with liquid nutrient drink test found that excessive gastric distension provokes dysrhythmias that are closely associated with foregut symptoms, supporting the role of disrupted gastric myoelectrical function in the pathophysiology of neurogastroduodenal disorders.

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来源期刊
CiteScore
9.40
自引率
2.20%
发文量
104
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Gastrointestinal and Liver Physiology publishes original articles pertaining to all aspects of research involving normal or abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. Authors are encouraged to submit manuscripts dealing with growth and development, digestion, secretion, absorption, metabolism, and motility relative to these organs, as well as research reports dealing with immune and inflammatory processes and with neural, endocrine, and circulatory control mechanisms that affect these organs.
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