{"title":"血管周围脂肪组织、白色脂肪组织和棕色脂肪组织在乙醇病理生理效应中的作用。","authors":"Thales M H Dourado, Carlos R Tirapelli","doi":"10.1016/j.ajpath.2025.07.012","DOIUrl":null,"url":null,"abstract":"<p><p>Adipose tissue plays a crucial role in energy storage, but it also acts as an endocrine organ by secreting hormones and proinflammatory molecules. It regulates various processes, including adipogenesis, metabolism, and inflammation. White and brown adipose tissue (WAT and BAT) consists of white and brown adipocytes, respectively, which differ in cellular structure and function. Adipocytes also make up a significant part of perivascular adipose tissue (PVAT), which forms a sheath-like structure around blood vessels. Current research indicates that WAT, BAT, and PVAT are negatively affected by ethanol (ethyl alcohol). The changes induced by ethanol in the storage, metabolic, and secretory functions of PVAT and WAT are linked to vascular and hepatic dysfunction. In this context, while adipose tissue is a target of the harmful effects of ethanol, it also contributes to its pathophysiological consequences. Although the function of BAT is impacted by ethanol, BAT exhibits a protective role against ethanol-induced liver disease. This review highlights both past and recent efforts to identify the mechanisms through which ethanol consumption alters adipocyte function, with a focus on findings from studies that explain the detrimental effects of ethanol on WAT and BAT, and discusses the interplay between adipose tissue and the liver, particularly its implications for alcoholic liver disease. Additionally, new data that elucidate the mechanisms underlying ethanol-induced dysfunction in PVAT are summarized.</p>","PeriodicalId":7623,"journal":{"name":"American Journal of Pathology","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Role of Perivascular Adipose Tissue, White Adipose Tissue, and Brown Adipose Tissue in the Pathophysiological Effects of Ethanol.\",\"authors\":\"Thales M H Dourado, Carlos R Tirapelli\",\"doi\":\"10.1016/j.ajpath.2025.07.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Adipose tissue plays a crucial role in energy storage, but it also acts as an endocrine organ by secreting hormones and proinflammatory molecules. It regulates various processes, including adipogenesis, metabolism, and inflammation. White and brown adipose tissue (WAT and BAT) consists of white and brown adipocytes, respectively, which differ in cellular structure and function. Adipocytes also make up a significant part of perivascular adipose tissue (PVAT), which forms a sheath-like structure around blood vessels. Current research indicates that WAT, BAT, and PVAT are negatively affected by ethanol (ethyl alcohol). The changes induced by ethanol in the storage, metabolic, and secretory functions of PVAT and WAT are linked to vascular and hepatic dysfunction. In this context, while adipose tissue is a target of the harmful effects of ethanol, it also contributes to its pathophysiological consequences. Although the function of BAT is impacted by ethanol, BAT exhibits a protective role against ethanol-induced liver disease. This review highlights both past and recent efforts to identify the mechanisms through which ethanol consumption alters adipocyte function, with a focus on findings from studies that explain the detrimental effects of ethanol on WAT and BAT, and discusses the interplay between adipose tissue and the liver, particularly its implications for alcoholic liver disease. Additionally, new data that elucidate the mechanisms underlying ethanol-induced dysfunction in PVAT are summarized.</p>\",\"PeriodicalId\":7623,\"journal\":{\"name\":\"American Journal of Pathology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Pathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajpath.2025.07.012\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajpath.2025.07.012","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
The Role of Perivascular Adipose Tissue, White Adipose Tissue, and Brown Adipose Tissue in the Pathophysiological Effects of Ethanol.
Adipose tissue plays a crucial role in energy storage, but it also acts as an endocrine organ by secreting hormones and proinflammatory molecules. It regulates various processes, including adipogenesis, metabolism, and inflammation. White and brown adipose tissue (WAT and BAT) consists of white and brown adipocytes, respectively, which differ in cellular structure and function. Adipocytes also make up a significant part of perivascular adipose tissue (PVAT), which forms a sheath-like structure around blood vessels. Current research indicates that WAT, BAT, and PVAT are negatively affected by ethanol (ethyl alcohol). The changes induced by ethanol in the storage, metabolic, and secretory functions of PVAT and WAT are linked to vascular and hepatic dysfunction. In this context, while adipose tissue is a target of the harmful effects of ethanol, it also contributes to its pathophysiological consequences. Although the function of BAT is impacted by ethanol, BAT exhibits a protective role against ethanol-induced liver disease. This review highlights both past and recent efforts to identify the mechanisms through which ethanol consumption alters adipocyte function, with a focus on findings from studies that explain the detrimental effects of ethanol on WAT and BAT, and discusses the interplay between adipose tissue and the liver, particularly its implications for alcoholic liver disease. Additionally, new data that elucidate the mechanisms underlying ethanol-induced dysfunction in PVAT are summarized.
期刊介绍:
The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.