锰催化多氮杂芳香化合物的不对称加氢反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-03 DOI:10.1021/acs.orglett.5c02777

Zheng Liu, Yan-Jiang Yu, Gao-Wei Wang, Sheng-Mei Lu, Yong-Gui Zhou and Mu-Wang Chen*,

引用次数: 0

摘要

以手性nnp -锰配合物为催化剂，成功地开发了包括5-或7-取代吡唑[1,5-a]嘧啶、吡唑[1,2-a]吡嗪和咪唑[1,2-a]吡嗪在内的多氮芳香族杂环的不对称加氢反应，提供了相应的还原产物，具有高的对映选择性、反应活性和广泛的底物范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Manganese-Catalyzed Asymmetric Hydrogenation of Multi-Nitrogen Heteroaromatic Compounds

查看原文本刊更多论文

Manganese-Catalyzed Asymmetric Hydrogenation of Multi-Nitrogen Heteroaromatic Compounds

Using the chiral NNP-manganese complex as catalyst, asymmetric hydrogenation of multi-nitrogen aromatic heterocycles including 5- or 7-substituted pyrazolo[1,5-a]pyrimidines, pyrrolo[1,2-a]pyrazines, and imidazo[1,2-a]pyrazines has been successfully developed, providing the corresponding reductive products with high enantioselectivity, reactivity, and wide substrate scope.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.