区域哮喘指南对英格兰SABA处方模式的影响：一个中断的时间序列分析

IF 7.7 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2025-09-02 DOI:10.1136/thorax-2025-223239

Dominic L Sykes, Michael D Clarkson, Anita Negbenebor, Helena Cummings, Shoaib Faruqi, Oscar Lau, Niranjanlal Ahilal, Michael G Crooks

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引用次数: 0

摘要

2024年英国胸科学会/国家健康与护理卓越研究所/苏格兰校际指南网络哮喘指南推荐基于抗炎缓解剂（AIR）的管理，为减少短效β受体激动剂（SABA）的过度使用提供了机会。许多英国地区也发布了当地的指导方针。对34个地区指南的分析使其可以分为三类：首先是SABA，吸入皮质类固醇（ICS）加上SABA和AIR（按需AIR），基于推荐的初始治疗。使用公开数据的中断时间序列分析表明，AIR指南的发布导致了SABA处方的最大下降，表示为所有含ics和SABA吸入器处方的比例(AIR: - 0.26% （SD 0.09%）每月；sba优先：每月- 0.1% (SD 0.03%)，与AIR相比p=0.001；ICS + SABA：每月−0.16% (SD 0.06%), p=0.004，与AIR相比)。因此，区域指南确实会影响当地的处方实践，与最新的国家建议保持一致可以改善哮喘处方和由此产生的患者结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Impact of regional asthma guidelines on SABA prescribing patterns across England: an interrupted time series analysis

The 2024 British Thoracic Society/ National Institute for Health and Care Excellence/ Scottish Intercollegiate Guidelines Network asthma guidelines recommend anti-inflammatory reliever (AIR)-based management, providing opportunity to reduce short-acting beta agonist (SABA) over-use. Many English regions also publish local guidelines. Analysis of 34 regional guidelines enabled grouping into three categories: SABA-first, inhaled corticosteroid (ICS) plus SABA and AIR (as-needed AIR), based on recommended initial treatment. Interrupted time series analysis using publicly available data demonstrated that AIR guideline publication resulted in the greatest decline in SABA prescribing, expressed as the proportion of all ICS-containing and SABA inhaler prescriptions (AIR: −0.26% (SD 0.09%) per month; SABA-first: −0.1% (SD 0.03%) per month, p=0.001 vs AIR; and ICS plus SABA: −0.16% (SD 0.06%) per month, p=0.004, vs AIR). Therefore, regional guidelines do affect local prescribing practice and alignment with the latest national recommendations could improve asthma prescribing and resulting patient outcomes.

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.