Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson
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Natural Killer Cells Are Dispensable for Virus Control in Rag2−/− Mice During Primary RSV Infection
Respiratory syncytial virus (RSV) is one of the major causes of severe lower respiratory tract infections, especially in children, the elderly, and immunocompromised individuals. Complications arising from viral infections in these age groups can present therapeutic challenges, as most of these individuals have impaired adaptive immunity. Using the T- and B cell-deficient Rag2−/− mice, the mechanisms that mediate protection in immunocompromised hosts during RSV infection can be investigated. RSV-infected Rag2−/− mice showed no symptoms of disease or chronic inflammation in the lungs and airways despite the presence of infectious virus in their lungs several months after infection. Interestingly, Natural Killer (NK) cells, the main innate cells with anti-viral cytotoxic effector functions, were recruited 2 days earlier in the lungs of Rag2−/− mice compared with wildtype mice, resulting in early production of IFN-γ. However, depletion of NK cells did not affect disease severity or viral load. Together, these results suggest that the NK cells are largely dispensable for virus control during primary RSV infection in Rag2−/− mice.
期刊介绍:
The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.