循环B细胞和CD4+ T细胞的扰动可区分多发性硬化症与其他中枢神经系统自身免疫性疾病

IF 3.7 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-09-03 DOI:10.1002/eji.70049

Laurens Bogers, Jasper Rip, Suzanne C. Franken, Kirsten L. Kuiper, Ana M. Marques, Annet F. Wierenga-Wolf, Marie-José Melief, Cato E. A. Corsten, Romy A. M. Klein Kranenbarg, Janet de Beukelaar, Ide Smets, Beatrijs H. Wokke, Maarten J. Titulaer, Joost Smolders, Marvin M. van Luijn

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引用次数: 0

摘要

利用流式细胞术，我们分析了未接受治疗的多发性硬化症（MS）和其他中枢神经系统自身免疫性疾病（CNS AIDs）患者的循环淋巴细胞亚群。b细胞和CD4+ t细胞频率升高是MS的疾病特异性特征，而T-bet+和CXCR3+ b细胞水平降低与疾病进展相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases

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Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases

Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4⁺ T-cell frequencies were a disease-specific feature of MS, while reduced T-bet⁺ and CXCR3⁺ B-cell levels were associated with progressive disease.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.