全身性自身炎性疾病患者与健康对照者多功能性单细胞基线差异

IF 3.7 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-09-03 DOI:10.1002/eji.70047

Aline Linder, Farah Diab, Loïc de Pontual, Irina Giurgea, Klaus Eyer

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引用次数: 0

摘要

细胞因子分泌和信号传导失调是系统性自身炎症性疾病的基础。在这里，我们通过分析单细胞水平的细胞因子分泌来表征SAID患者的免疫失调，建立分泌动力学和细胞多功能性的测量，与健康对照组相比，揭示了供体之间免疫反应的自然变异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls

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Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls

Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.