细胞化妆品:先天淋巴细胞如何重塑肿瘤微环境

IF 3.7 3区 医学 Q2 IMMUNOLOGY
Nabina Pun, David R. Withers
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引用次数: 0

摘要

先天淋巴样细胞(ILC)家族包括自然杀伤细胞(NK),已被识别超过50年,以及最近发现的几个群体。在过去的15年中,ilc已成为组织稳态和炎症的关键协调者。为了建立癌症免疫疗法的早期前景,有必要更好地了解控制许多实体癌症的组成和免疫抑制机制的途径,并有效地减少或阻断T细胞反应。鉴于它们存在于大多数组织中,这些细胞哨兵如何影响肿瘤的发生和进展仍然是一个活跃的发现领域,也是更多以翻译为重点的研究领域。通过精确定义不同的免疫抑制途径是如何形成的,可以设计合理的免疫治疗组合来专门针对这些。目前的证据表明,对于每个ILC亚群,促肿瘤和抗肿瘤的作用都是可能的,可能反映了不同组织和环境中的局部线索。在这里,我们试图简明地回顾一些描述ILC对肿瘤免疫贡献的主流数据,并强调在充分剖析这些机制方面仍然存在的一些挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment

Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment

The innate lymphoid cell (ILC) family includes natural killer (NK) cells, recognised for over 50 years, as well as several more recently identified populations. Over the past 15 years, ILCs have emerged as key orchestrators of tissue homeostasis and inflammation. To build upon the early promise of cancer immunotherapies, it is essential to better understand the pathways regulating the composition of, and immunosuppressive mechanisms that dominate many solid cancers and effectively curtail or block T cell responses. Given their residence within most tissues, how these cellular sentinels influence tumour development and progression remains an active area of both discovery and more translationally focused research. By defining precisely how different immunosuppressive pathways form, rationalised immunotherapy combinations can be devised to specifically target these. Current evidence indicates that for each ILC subset, both pro- and anti-tumourigenic roles are possible, likely reflecting local cues within different tissues and contexts. Here, we seek to concisely review some of the prevailing data describing ILC contributions to tumour immunity and highlight some of the challenges that still exist in fully dissecting these mechanisms.

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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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