Lolyta Fitri Mustati, Annisa Hana Mufidah, Harris Antonius, Yuli Widiyastuti, Eldiza Puji Rahmi, Yuandani, Tri Yuliani, Abdi Wira Septama
{"title":"爪哇姜黄精油转移体纳米载体的研制及其生物活性评价","authors":"Lolyta Fitri Mustati, Annisa Hana Mufidah, Harris Antonius, Yuli Widiyastuti, Eldiza Puji Rahmi, Yuandani, Tri Yuliani, Abdi Wira Septama","doi":"10.1007/s10068-025-01933-9","DOIUrl":null,"url":null,"abstract":"<div><p><i>Curcuma xanthorrhiza</i> essential oils (CXEO) are widely used in many different sectors. Although CXEO's intriguing properties, its poor solubility and volatility have restricted its use. Thus, the study aimed to fabricate and characterize stable CXEO transferosome. The antibacterial, antioxidant and anti-inflammatory activities of this vesicle are determined. The optimized transferosomes entrapped 94.55 ± 2.78% of CXEO with particle size of 126.4 ± 2.4 nm, polydispersity index of 0.78 ± 0.01, and zeta potential value of -30.7 ± 0.2. CXEO-transferosome exhibited strong antibacterial activity against <i>Staphylococcus epidermidis</i> and <i>Propionibacterium acnes</i> with MIC values of 15.6 and 7.8 μg/mL, respectively. CXEO-transferosomes showed activity against DPPH and ABTS radicals with IC<sub>50</sub> values of 258.50 ± 0.20 and 79.79 ± 0.04 μg/mL, respectively. Transferosome also possessed anti-inflammatory activity (21.82 ± 0.50%). The finding indicated that CXEO-transferosome enable to improve the biological activities of free CXEO and this product can be extended to relevant applications.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 14","pages":"3225 - 3236"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of transfersomal nanocarriers loaded with Javanese turmeric essential oils and evaluation of their biological activity\",\"authors\":\"Lolyta Fitri Mustati, Annisa Hana Mufidah, Harris Antonius, Yuli Widiyastuti, Eldiza Puji Rahmi, Yuandani, Tri Yuliani, Abdi Wira Septama\",\"doi\":\"10.1007/s10068-025-01933-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><i>Curcuma xanthorrhiza</i> essential oils (CXEO) are widely used in many different sectors. Although CXEO's intriguing properties, its poor solubility and volatility have restricted its use. Thus, the study aimed to fabricate and characterize stable CXEO transferosome. The antibacterial, antioxidant and anti-inflammatory activities of this vesicle are determined. The optimized transferosomes entrapped 94.55 ± 2.78% of CXEO with particle size of 126.4 ± 2.4 nm, polydispersity index of 0.78 ± 0.01, and zeta potential value of -30.7 ± 0.2. CXEO-transferosome exhibited strong antibacterial activity against <i>Staphylococcus epidermidis</i> and <i>Propionibacterium acnes</i> with MIC values of 15.6 and 7.8 μg/mL, respectively. CXEO-transferosomes showed activity against DPPH and ABTS radicals with IC<sub>50</sub> values of 258.50 ± 0.20 and 79.79 ± 0.04 μg/mL, respectively. Transferosome also possessed anti-inflammatory activity (21.82 ± 0.50%). The finding indicated that CXEO-transferosome enable to improve the biological activities of free CXEO and this product can be extended to relevant applications.</p></div>\",\"PeriodicalId\":566,\"journal\":{\"name\":\"Food Science and Biotechnology\",\"volume\":\"34 14\",\"pages\":\"3225 - 3236\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Biotechnology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10068-025-01933-9\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Biotechnology","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1007/s10068-025-01933-9","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Development of transfersomal nanocarriers loaded with Javanese turmeric essential oils and evaluation of their biological activity
Curcuma xanthorrhiza essential oils (CXEO) are widely used in many different sectors. Although CXEO's intriguing properties, its poor solubility and volatility have restricted its use. Thus, the study aimed to fabricate and characterize stable CXEO transferosome. The antibacterial, antioxidant and anti-inflammatory activities of this vesicle are determined. The optimized transferosomes entrapped 94.55 ± 2.78% of CXEO with particle size of 126.4 ± 2.4 nm, polydispersity index of 0.78 ± 0.01, and zeta potential value of -30.7 ± 0.2. CXEO-transferosome exhibited strong antibacterial activity against Staphylococcus epidermidis and Propionibacterium acnes with MIC values of 15.6 and 7.8 μg/mL, respectively. CXEO-transferosomes showed activity against DPPH and ABTS radicals with IC50 values of 258.50 ± 0.20 and 79.79 ± 0.04 μg/mL, respectively. Transferosome also possessed anti-inflammatory activity (21.82 ± 0.50%). The finding indicated that CXEO-transferosome enable to improve the biological activities of free CXEO and this product can be extended to relevant applications.
期刊介绍：
The FSB journal covers food chemistry and analysis for compositional and physiological activity changes, food hygiene and toxicology, food microbiology and biotechnology, and food engineering involved in during and after food processing through physical, chemical, and biological ways. Consumer perception and sensory evaluation on processed foods are accepted only when they are relevant to the laboratory research work. As a general rule, manuscripts dealing with analysis and efficacy of extracts from natural resources prior to the processing or without any related food processing may not be considered within the scope of the journal. The FSB journal does not deal with only local interest and a lack of significant scientific merit. The main scope of our journal is seeking for human health and wellness through constructive works and new findings in food science and biotechnology field.
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