Sang-Yong Han, Hangyul Choi, Eun-Heui Jo, Yun-Kyung Kim
{"title":"枸杞子水提取物及其活性成分玉米黄质对核因子κB配体诱导的破骨细胞分化受体激活因子的抑制作用","authors":"Sang-Yong Han, Hangyul Choi, Eun-Heui Jo, Yun-Kyung Kim","doi":"10.1007/s10068-025-01944-6","DOIUrl":null,"url":null,"abstract":"<div><p>Lycii fructus (LF) is widely used in traditional Asian medicine and as a dietary supplement due to its potential health benefits. Zeaxanthin (ZEA), a key carotenoid in LF, is crucial in supporting eye health. However, the effects of LF and ZEA on receptor activator of NF-kappaB Ligand (RANKL)-mediated osteoclast differentiation were not confirmed. This study evaluated the anti-osteoclastogenic effects of LF water extracts (LFW) and ZEA. LFW and ZEA inhibited RANKL-induced TRAP formation and F-actin rings in BMMs. LFW and ZEA suppressed mRNA and protein expression of c-Fos and NFATc1. LFW and ZEA stimulation also led to the suppression of mRNA expression for osteoclast-specific genes. In MAPK signaling pathways, LFW suppressed ERK, JNK, and p38 phosphorylation, while ZEA only inhibited the JNK pathway. Taken together, LFW and ZEA have the potential to be used as organic functional foods for the prevention and treatment of bone diseases.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"34 14","pages":"3363 - 3374"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inhibitory effects of Lycii fructus water extracts and its active ingredient, zeaxanthin, on receptor activator of nuclear factor κB ligand-induced osteoclast differentiation\",\"authors\":\"Sang-Yong Han, Hangyul Choi, Eun-Heui Jo, Yun-Kyung Kim\",\"doi\":\"10.1007/s10068-025-01944-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lycii fructus (LF) is widely used in traditional Asian medicine and as a dietary supplement due to its potential health benefits. Zeaxanthin (ZEA), a key carotenoid in LF, is crucial in supporting eye health. However, the effects of LF and ZEA on receptor activator of NF-kappaB Ligand (RANKL)-mediated osteoclast differentiation were not confirmed. This study evaluated the anti-osteoclastogenic effects of LF water extracts (LFW) and ZEA. LFW and ZEA inhibited RANKL-induced TRAP formation and F-actin rings in BMMs. LFW and ZEA suppressed mRNA and protein expression of c-Fos and NFATc1. LFW and ZEA stimulation also led to the suppression of mRNA expression for osteoclast-specific genes. In MAPK signaling pathways, LFW suppressed ERK, JNK, and p38 phosphorylation, while ZEA only inhibited the JNK pathway. Taken together, LFW and ZEA have the potential to be used as organic functional foods for the prevention and treatment of bone diseases.</p></div>\",\"PeriodicalId\":566,\"journal\":{\"name\":\"Food Science and Biotechnology\",\"volume\":\"34 14\",\"pages\":\"3363 - 3374\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Biotechnology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10068-025-01944-6\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Biotechnology","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1007/s10068-025-01944-6","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Inhibitory effects of Lycii fructus water extracts and its active ingredient, zeaxanthin, on receptor activator of nuclear factor κB ligand-induced osteoclast differentiation
Lycii fructus (LF) is widely used in traditional Asian medicine and as a dietary supplement due to its potential health benefits. Zeaxanthin (ZEA), a key carotenoid in LF, is crucial in supporting eye health. However, the effects of LF and ZEA on receptor activator of NF-kappaB Ligand (RANKL)-mediated osteoclast differentiation were not confirmed. This study evaluated the anti-osteoclastogenic effects of LF water extracts (LFW) and ZEA. LFW and ZEA inhibited RANKL-induced TRAP formation and F-actin rings in BMMs. LFW and ZEA suppressed mRNA and protein expression of c-Fos and NFATc1. LFW and ZEA stimulation also led to the suppression of mRNA expression for osteoclast-specific genes. In MAPK signaling pathways, LFW suppressed ERK, JNK, and p38 phosphorylation, while ZEA only inhibited the JNK pathway. Taken together, LFW and ZEA have the potential to be used as organic functional foods for the prevention and treatment of bone diseases.
期刊介绍：
The FSB journal covers food chemistry and analysis for compositional and physiological activity changes, food hygiene and toxicology, food microbiology and biotechnology, and food engineering involved in during and after food processing through physical, chemical, and biological ways. Consumer perception and sensory evaluation on processed foods are accepted only when they are relevant to the laboratory research work. As a general rule, manuscripts dealing with analysis and efficacy of extracts from natural resources prior to the processing or without any related food processing may not be considered within the scope of the journal. The FSB journal does not deal with only local interest and a lack of significant scientific merit. The main scope of our journal is seeking for human health and wellness through constructive works and new findings in food science and biotechnology field.
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