“好”脂肪，坏消息：高密度脂蛋白提供的维生素E保护肿瘤免于铁下垂

IF 52.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-09-02 DOI:10.1038/s41392-025-02373-x

Dong Wook Choi, Eun-Woo Lee

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引用次数: 0

摘要

Calhoon等人最近发表在《自然》杂志上的一项研究报告称，糖胺聚糖（GAG）介导的脂蛋白摄取通过传递α-生育酚（维生素E的最丰富形式）来保护癌细胞免受铁死症的侵害。这一发现为靶向GAG依赖的脂质摄取或调节膳食维生素E提供了潜在的治疗机会，以增强基于铁死症的癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

“Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis

查看原文本刊更多论文

“Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis

In a recent study published in Nature, Calhoon et al.¹ reported that glycosaminoglycan (GAG)-mediated uptake of lipoproteins protects cancer cells from ferroptosis by delivering α-tocopherol, the most abundant form of vitamin E. This discovery offers potential therapeutic opportunities to either target GAG-dependent lipid uptake or modulate dietary vitamin E to enhance ferroptosis-based cancer therapies.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.