用于三氟甲基化和芳基碘化物18f标记的稳定铜配合物

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-02 DOI:10.1021/acs.orglett.5c03171

Ji Young Choi, Ewa Pietrasiak, Nakeun Ko, Seok-Yong Lee, Hyewon Youn, Jaelim Kim, Eunsung Lee and Byung Chul Lee*,

{"title":"用于三氟甲基化和芳基碘化物18f标记的稳定铜配合物","authors":"Ji Young Choi, Ewa Pietrasiak, Nakeun Ko, Seok-Yong Lee, Hyewon Youn, Jaelim Kim, Eunsung Lee and Byung Chul Lee*, ","doi":"10.1021/acs.orglett.5c03171","DOIUrl":null,"url":null,"abstract":"Here, we report an efficient and highly active copper complex ([(TMPhen)2Cu(I)][O2CCF2Cl]) for the trifluoromethylation of aryl iodides. This bench-stable copper complex converts aryl iodides into their corresponding CF3 derivatives in high yields within 1 h. The protocol is also well-suited for aromatic [18F]trifluoromethylation, offering a rapid and efficient approach for the development of new radiopharmaceuticals within 20 min.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"27 36","pages":"10110–10115"},"PeriodicalIF":5.0000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bench-Stable Copper Complex for Trifluoromethylation and 18F-Labeling of Aryl Iodides\",\"authors\":\"Ji Young Choi, Ewa Pietrasiak, Nakeun Ko, Seok-Yong Lee, Hyewon Youn, Jaelim Kim, Eunsung Lee and Byung Chul Lee*, \",\"doi\":\"10.1021/acs.orglett.5c03171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Here, we report an efficient and highly active copper complex ([(TMPhen)2Cu(I)][O2CCF2Cl]) for the trifluoromethylation of aryl iodides. This bench-stable copper complex converts aryl iodides into their corresponding CF3 derivatives in high yields within 1 h. The protocol is also well-suited for aromatic [18F]trifluoromethylation, offering a rapid and efficient approach for the development of new radiopharmaceuticals within 20 min.\",\"PeriodicalId\":54,\"journal\":{\"name\":\"Organic Letters\",\"volume\":\"27 36\",\"pages\":\"10110–10115\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.orglett.5c03171\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.orglett.5c03171","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

在这里，我们报道了一个高效和高活性的铜配合物([（TMPhen)2Cu(I)][O2CCF2Cl]）用于芳基碘化物的三氟甲基化。这种稳定的铜配合物在1小时内高收率地将芳基碘化物转化为相应的CF3衍生物。该方案也非常适合芳香[18F]三氟甲基化，为在20分钟内开发新的放射性药物提供了快速有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bench-Stable Copper Complex for Trifluoromethylation and 18F-Labeling of Aryl Iodides

查看原文本刊更多论文

Bench-Stable Copper Complex for Trifluoromethylation and 18F-Labeling of Aryl Iodides

Here, we report an efficient and highly active copper complex ([(TMPhen)₂Cu(I)][O₂CCF₂Cl]) for the trifluoromethylation of aryl iodides. This bench-stable copper complex converts aryl iodides into their corresponding CF₃ derivatives in high yields within 1 h. The protocol is also well-suited for aromatic [¹⁸F]trifluoromethylation, offering a rapid and efficient approach for the development of new radiopharmaceuticals within 20 min.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.