蠕虫和生殖失败:经胎盘传播导致马反复流产的第一个证据

IF 1.7 Q3 PARASITOLOGY
Andrea Springer , Christin Krüger , Christina Strube , Dirk Steinhauer
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引用次数: 0

摘要

同时性寄生哈利头线虫的感染在动物和人类中通常是致命的。本文首次描述了一种Halicephalobus的经胎盘传播,导致母马在连续两次妊娠期间生殖失败。在这两个病例中,组织学显示成虫和幼虫在胎盘和各种胎儿器官中都有线虫,母马没有全身性线虫病的迹象。从两个胎盘中获得的相同的18S rRNA-ITS1-5.8S rRNA-ITS2序列与先前测序的马分离物显示出相当大的差异,表明脊椎动物中Halicephalobus分离物存在隐性多样性。这种无处不在的线虫可能是导致马流产的原因,并造成相当大的经济损失。未来的研究应着眼于探索有效的治疗方案,并澄清海胆属的真正分类多样性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Worms and reproductive failure: First evidence of transplacental Halicephalobus transmission leading to repeated equine abortion

Worms and reproductive failure: First evidence of transplacental Halicephalobus transmission leading to repeated equine abortion
Infections with facultatively parasitic Halicephalobus spp. nematodes are usually fatal in animals and humans. Here, transplacental transmission of a species of Halicephalobus is described for the first time, causing reproductive failure of a mare during two consecutive gestations. In both cases, histology showed adult and larval nematodes in the placenta and various foetal organs, without signs of generalized halicephalobosis in the mare. An identical 18S rRNA-ITS1-5.8S rRNA-ITS2 sequence generated from both placentas showed considerable divergence from a previously sequenced equine isolate, suggesting cryptic diversity among Halicephalobus isolates in vertebrates. This ubiquitous nematode may be a cause of equine abortion associated with considerable economic loss. Future research should aim at exploring effective treatment options and clarifying the true taxonomic diversity within the genus Halicephalobus.
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