生物引导剂量成像在质子治疗中的技术可行性评价

IF 3.3 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2025-07-01 DOI:10.1016/j.phro.2025.100832

Caterina Brighi , Giovanni Parrella , Letizia Morelli , Silvia Molinelli , Giuseppe Magro , Sara Lillo , Alberto Iannalfi , Mario Ciocca , Sara Imparato , David E.J. Waddington , Paul Keall , Chiara Paganelli , Ester Orlandi , Guido Baroni

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引用次数: 0

摘要

对10例颅底脊索瘤患者采用扩散加权磁共振成像进行质子治疗的技术可行性进行了评价。患者特异性DP处方根据肿瘤细胞生成，并在临床治疗计划系统中实施。与统一方案相比，DP达到了较低的符合性（尽管达到97%），改善了目标剂量指标，减少了对大多数危险器官的剂量，并在不超出临床限制的情况下增加了肿瘤控制的可能性。DP质子治疗在技术上是可行的，可以提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Evaluating the technical feasibility of biology-guided dose painting in proton therapy

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Evaluating the technical feasibility of biology-guided dose painting in proton therapy

Biology-guided voxel-level inverse prescription mapping for dose painting (DP) using diffusion-weighted magnetic resonance imaging was evaluated for technical feasibility in proton therapy for 10 skull-base chordoma patients. Patient-specific DP prescriptions were generated from tumour cellularity and implemented in a clinical treatment planning system. Compared with uniform plans, DP achieved lower conformity (although >97 %), improved target dose metrics, reduced doses to most organs at risk, and increased tumour control probability without exceeding clinical constraints. DP proton therapy is technically feasible and may enhance treatment effectiveness.

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来源期刊

Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation

CiteScore

5.30

自引率

18.90%

发文量

审稿时长

6 weeks