用于光开关药物原位激活的3D打印玻璃基生物光子支架

IF 6.2 2区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Journal of The European Ceramic Society Pub Date : 2025-08-27 DOI:10.1016/j.jeurceramsoc.2025.117777

Evellyn Santos Magalhães , Nirajan Ojha , Sonya Ghanavati , Ekin Opar , Philippe F. Smet , Mika Lastusaari , Fabio Riefolo , Carlo Matera , Jonathan Massera , Pau Gorostiza , Laeticia Petit

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引用次数: 0

摘要

本文报道了利用机器铸造技术制备多孔生物光子支架。这种材料可以用于光开关药物的原位活化，这对于提高治疗效果同时最小化副作用至关重要。该支架由磷酸盐玻璃制成，混合了CaWO₄：Yb³ +、Tm³ +晶体和SrAl₂O₄：Eu²+、Dy³ +荧光粉。在980 nm照射下，支架发出蓝光和绿色余光，随着近红外光穿透组织，支架在植入后被原位激活。讨论了与烧结工艺相关的挑战及其对支架光谱性能的影响。3d打印的支架成功地使人们能够在近红外激发下激活毒菌碱光开关药物邻氮偶氮苯Iperoxo (PAI)，证实了利用组织透性光刺激原位光触发传递药物作用的潜力。

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3D printed glass-based biophotonic scaffolds for in situ activation of photoswitchable drugs

The fabrication of porous biophotonic scaffold using a robocasting is reported here. Such material could be used for in-situ activation of photoswitchable drugs, which is essential for improving therapeutic efficacy while minimizing side effects. The scaffold is made of a phosphate glass mixed with CaWO₄:Yb³ ⁺,Tm³ ⁺ crystals and SrAl₂O₄:Eu²⁺,Dy³ ⁺ phosphors. Upon 980 nm irradiation, the scaffold emits blue light and green afterglow, enabling in-situ activation post-implantation as NIR light penetrates tissue. The challenges related to the sintering process and its effect on the spectroscopic properties of the scaffold are discussed. The as-3D printed scaffold successfully enables one to activate the muscarinic photoswitchable drug Phthal Azobenzene Iperoxo (PAI) upon NIR excitation, confirming the potential for in-situ phototriggered delivery of drug action using tissue-permeable light stimulus.

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来源期刊

Journal of The European Ceramic Society 工程技术-材料科学：硅酸盐

CiteScore

10.70

自引率

12.30%

发文量

863

审稿时长

35 days

期刊介绍： The Journal of the European Ceramic Society publishes the results of original research and reviews relating to ceramic materials. Papers of either an experimental or theoretical character will be welcomed on a fully international basis. The emphasis is on novel generic science concerning the relationships between processing, microstructure and properties of polycrystalline ceramics consolidated at high temperature. Papers may relate to any of the conventional categories of ceramic: structural, functional, traditional or composite. The central objective is to sustain a high standard of research quality by means of appropriate reviewing procedures.