Ramazan Danis, Eren Eynel, Jehat Kilic, Nurettin Ay
{"title":"那不勒斯预后评分可能与肾移植患者的急性排斥反应有关：单中心经验","authors":"Ramazan Danis, Eren Eynel, Jehat Kilic, Nurettin Ay","doi":"10.1111/ctr.70294","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>The Naples Prognostic Score (NPS) is a comprehensive measure of patients' inflammatory and nutritional status. In this study, we compared the preoperative NPS of kidney transplant recipients who experienced acute rejection (AR) with those who did not.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>This retrospective study included 294 patients who underwent kidney transplantation and were followed up at our hospital between January 2012 and January 2024. NPS was calculated based on laboratory values obtained 1 day before the transplantation surgery. Patients were divided into two groups according to the occurrence of biopsy-proven acute rejection (AR): Group A consisted of patients who developed AR, and Group B comprised those without AR.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Our analysis revealed a significant difference between Group A and Group B regarding donor type (living or cadaveric) (<i>p</i> = 0.016). Furthermore, a significant difference was observed in the comparison of the Naples Prognostic Score (<i>p</i> = 0.014). The subsequent multivariate analysis showed that cadaveric donor status significantly increased the risk of acute rejection (HR = 2.935 [95% CI, 1.250–6.893], <i>p</i> = 0.013). Additionally, patients with a Naples score of 3–4 had a higher risk of acute rejection compared to those with a score of 0–2 (HR = 2.142 [95% CI, 1.160–3.955], <i>p</i> = 0.015).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Preoperative Naples Prognostic Score, may influence the risk of acute rejection in the postoperative period. A higher NPS is associated with an increased risk of acute rejection, which may subsequently lead to graft dysfunction.</p>\n </section>\n </div>","PeriodicalId":10467,"journal":{"name":"Clinical Transplantation","volume":"39 9","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Naples Prognostic Score May Be Associated With Acute Rejection in Kidney Transplant Patients: A Single Center Experience\",\"authors\":\"Ramazan Danis, Eren Eynel, Jehat Kilic, Nurettin Ay\",\"doi\":\"10.1111/ctr.70294\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The Naples Prognostic Score (NPS) is a comprehensive measure of patients' inflammatory and nutritional status. In this study, we compared the preoperative NPS of kidney transplant recipients who experienced acute rejection (AR) with those who did not.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>This retrospective study included 294 patients who underwent kidney transplantation and were followed up at our hospital between January 2012 and January 2024. NPS was calculated based on laboratory values obtained 1 day before the transplantation surgery. Patients were divided into two groups according to the occurrence of biopsy-proven acute rejection (AR): Group A consisted of patients who developed AR, and Group B comprised those without AR.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Our analysis revealed a significant difference between Group A and Group B regarding donor type (living or cadaveric) (<i>p</i> = 0.016). Furthermore, a significant difference was observed in the comparison of the Naples Prognostic Score (<i>p</i> = 0.014). The subsequent multivariate analysis showed that cadaveric donor status significantly increased the risk of acute rejection (HR = 2.935 [95% CI, 1.250–6.893], <i>p</i> = 0.013). Additionally, patients with a Naples score of 3–4 had a higher risk of acute rejection compared to those with a score of 0–2 (HR = 2.142 [95% CI, 1.160–3.955], <i>p</i> = 0.015).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Preoperative Naples Prognostic Score, may influence the risk of acute rejection in the postoperative period. A higher NPS is associated with an increased risk of acute rejection, which may subsequently lead to graft dysfunction.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10467,\"journal\":{\"name\":\"Clinical Transplantation\",\"volume\":\"39 9\",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70294\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Transplantation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70294","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Naples Prognostic Score May Be Associated With Acute Rejection in Kidney Transplant Patients: A Single Center Experience
Background
The Naples Prognostic Score (NPS) is a comprehensive measure of patients' inflammatory and nutritional status. In this study, we compared the preoperative NPS of kidney transplant recipients who experienced acute rejection (AR) with those who did not.
Materials and Methods
This retrospective study included 294 patients who underwent kidney transplantation and were followed up at our hospital between January 2012 and January 2024. NPS was calculated based on laboratory values obtained 1 day before the transplantation surgery. Patients were divided into two groups according to the occurrence of biopsy-proven acute rejection (AR): Group A consisted of patients who developed AR, and Group B comprised those without AR.
Results
Our analysis revealed a significant difference between Group A and Group B regarding donor type (living or cadaveric) (p = 0.016). Furthermore, a significant difference was observed in the comparison of the Naples Prognostic Score (p = 0.014). The subsequent multivariate analysis showed that cadaveric donor status significantly increased the risk of acute rejection (HR = 2.935 [95% CI, 1.250–6.893], p = 0.013). Additionally, patients with a Naples score of 3–4 had a higher risk of acute rejection compared to those with a score of 0–2 (HR = 2.142 [95% CI, 1.160–3.955], p = 0.015).
Conclusions
Preoperative Naples Prognostic Score, may influence the risk of acute rejection in the postoperative period. A higher NPS is associated with an increased risk of acute rejection, which may subsequently lead to graft dysfunction.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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