缺牙数量与中风风险之间的关系：NHANES 2011-2020数据分析

IF 1.8 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2025-08-27 DOI:10.1016/j.jstrokecerebrovasdis.2025.108442

Dajin Li , Min You , Yan Rong , Lina Wang , Sijin Peng , Feifei Shi , Xiaoli Sun , Yueguang Liang , Ting Wang

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引用次数: 0

摘要

中风是全球第二大死亡原因和第三大残疾原因，严重影响生活质量并增加医疗保健费用。识别潜在的原因对于有效的管理至关重要。口腔健康与中风的发生密切相关，牙齿脱落是常见的口腔健康问题。然而，很少有研究探讨缺牙数量和中风之间的关系。本研究旨在阐明缺牙数量与中风之间的关系。方法本横断面研究利用了国家健康和营养检查调查（NHANES）的数据。缺牙的数量由专业牙医评估。为了研究牙齿脱落与卒中风险之间的关系，采用多变量logistic回归分析和限制三次样条（RCS）。进一步进行亚组分析，以验证不同人群研究结果的一致性。结果该研究纳入了23,473名成人参与者，其中4.19%有中风史。与没有中风的人相比，被诊断为中风的参与者显示出更多的牙齿缺失。在对多个变量进行调整的模型中，每增加一颗缺牙，卒中的可能性增加2% （OR = 1.02, 95% CI: 1.01, 1.03）。与没有牙齿缺失的参与者相比，全牙缺失的参与者中风发生率高163% （OR = 2.63, 95% CI: 1.90, 3.62）。RCS曲线显示缺牙数与卒中风险呈显著的非线性正相关。结论在美国成年人中，缺牙数量与中风呈显著正相关。进一步的大规模、严格控制的研究是有必要的，以验证这些发现的可靠性和普遍性。

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Association between number of missing teeth and stroke risk: an analysis of NHANES 2011-2020 data

Background

Stroke is the second leading cause of death globally and the third leading cause of disability, severely impacting quality of life and increasing healthcare costs. Identifying underlying causes is critical for effective management. Oral health is closely linked to stroke occurrence, and tooth loss is a common oral health issue. However, few studies have explored the relationship between the number of missing teeth and stroke. This study aimed to elucidate the association between the number of missing teeth and stroke.

Methods

This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES). The number of missing teeth was assessed by professional dentists. To examine the relationship between tooth loss and stroke risk, multivariable logistic regression analysis and restricted cubic splines (RCS) were employed. Subgroup analyses were further conducted to verify the consistency of findings across populations.

Results

The study enrolled 23,473 adult participants, of whom 4.19 % had a history of stroke. Participants diagnosed with stroke exhibited a higher number of missing teeth compared to those without stroke. In a model adjusted for multiple variables, each additional missing tooth was associated with a 2 % increased likelihood of stroke (OR = 1.02, 95 % CI: 1.01, 1.03). Participants with total tooth loss had a 163 % higher incidence of stroke compared to those with no missing teeth (OR = 2.63, 95 % CI: 1.90, 3.62). The RCS curve revealed a significant nonlinear positive correlation between the number of missing teeth and stroke risk.

Conclusions

A significant positive association between the number of missing teeth and stroke was observed among U.S. adults. Further large-scale, rigorously controlled studies are warranted to validate the reliability and generalizability of these findings.

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.