以异氰化物、磺胺和二硫化物为原料清洁经济地合成n -磺酰基异硫脲

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-08-28 DOI:10.1039/d5qo00867k

Changping Xun, Zhibin Nong, Kun Hu, Wenfeng Lv, Jiajun Zhao, Ziqiong Yin, Jialu Lv, Feng Jiang, Qing-Wen Gui

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引用次数: 0

摘要

以nBu4NI为氧化还原催化剂和电解质，研究了异氰化物、磺胺类和二硫化物的电化学三组分反应。在这一转变中观察到罕见的N-to-N [1,3]-H位移。该方法是合成n -磺酰基异硫脲的一种高效、经济的方法。

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Clean and Economic Synthesis of N-sulfonyl Isothioureas from Isocyanides, Sulfonamides and Disulfides

An electrochemical three-component reaction involving isocyanides, sulfonamides and disulfides was developed, using nBu4NI as a redox catalyst and electrolyte. A rare of N-to-N [1,3]-H shift was observed in this transformation. This method represents a highly efficient and cost-effective approach for the synthesis of N-sulfonyl isothioureas.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.