{"title":"lncRNA TMEM51-AS1降低有助于TNBC的进展及其术前DCE-MRI特征的复发诊断价值","authors":"Tian Song, Zhenfang Zhu, Kanhua Wu","doi":"10.1002/jbt.70436","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Long noncoding RNAs (lncRNAs) participate in various physiological and pathological processes of tumors and have a significant correlation with MRI radiomics. This study investigated the role of lncRNA TMEM51-AS1 in TNBC and probed the role of preoperative DCE-MRI combined with TMEM51-AS1 in risk stratification of postoperative recurrence of TNBC. Real-time quantitative PCR was used to detect the tissue TMEM51-AS1 expression after operation. According to the recurrence and metastasis of patients 1 year after surgery, patients were grouped into high-risk and low-risk groups. The value of preoperative DCE-MRI and TMEM51-AS1 in the assessment of postoperative recurrence and metastasis was analyzed using the receiver operating characteristic curve. CCK-8 and Transwell assays were performed to evaluate the influence of TMEM51-AS1 on TNBC cellular capacities. TMEM51-AS1 was decreased in TNBC tissues, especially in high-risk groups. TMEM51-AS1 expression, Max Slope, and Max Cone were risk factors associated with postoperative recurrent metastasis, and combined three had a high diagnostic value in predicting postoperative recurrent metastasis. Increased TMEM51-AS1 weakened TNBC cell proliferation, migration, and invasion by regulating miR-19a-3p. Combined preoperative DCE-MRI and TMEM51-AS1 testing may be used to predict the risk of postoperative recurrent metastasis in patients with TNBC. TMEM51-AS overexpression may repress TNBC progression by miR-19a-3p, which may guide the subsequent clinical management and improve the survival of TNBC patients.</p>\n </div>","PeriodicalId":15151,"journal":{"name":"Journal of Biochemical and Molecular Toxicology","volume":"39 9","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Decreased lncRNA TMEM51-AS1 Facilitates TNBC Progression and Its Diagnostic Value of Recurrence with Preoperative DCE-MRI Characteristics\",\"authors\":\"Tian Song, Zhenfang Zhu, Kanhua Wu\",\"doi\":\"10.1002/jbt.70436\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Long noncoding RNAs (lncRNAs) participate in various physiological and pathological processes of tumors and have a significant correlation with MRI radiomics. This study investigated the role of lncRNA TMEM51-AS1 in TNBC and probed the role of preoperative DCE-MRI combined with TMEM51-AS1 in risk stratification of postoperative recurrence of TNBC. Real-time quantitative PCR was used to detect the tissue TMEM51-AS1 expression after operation. According to the recurrence and metastasis of patients 1 year after surgery, patients were grouped into high-risk and low-risk groups. The value of preoperative DCE-MRI and TMEM51-AS1 in the assessment of postoperative recurrence and metastasis was analyzed using the receiver operating characteristic curve. CCK-8 and Transwell assays were performed to evaluate the influence of TMEM51-AS1 on TNBC cellular capacities. TMEM51-AS1 was decreased in TNBC tissues, especially in high-risk groups. TMEM51-AS1 expression, Max Slope, and Max Cone were risk factors associated with postoperative recurrent metastasis, and combined three had a high diagnostic value in predicting postoperative recurrent metastasis. Increased TMEM51-AS1 weakened TNBC cell proliferation, migration, and invasion by regulating miR-19a-3p. Combined preoperative DCE-MRI and TMEM51-AS1 testing may be used to predict the risk of postoperative recurrent metastasis in patients with TNBC. TMEM51-AS overexpression may repress TNBC progression by miR-19a-3p, which may guide the subsequent clinical management and improve the survival of TNBC patients.</p>\\n </div>\",\"PeriodicalId\":15151,\"journal\":{\"name\":\"Journal of Biochemical and Molecular Toxicology\",\"volume\":\"39 9\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biochemical and Molecular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbt.70436\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biochemical and Molecular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbt.70436","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Decreased lncRNA TMEM51-AS1 Facilitates TNBC Progression and Its Diagnostic Value of Recurrence with Preoperative DCE-MRI Characteristics
Long noncoding RNAs (lncRNAs) participate in various physiological and pathological processes of tumors and have a significant correlation with MRI radiomics. This study investigated the role of lncRNA TMEM51-AS1 in TNBC and probed the role of preoperative DCE-MRI combined with TMEM51-AS1 in risk stratification of postoperative recurrence of TNBC. Real-time quantitative PCR was used to detect the tissue TMEM51-AS1 expression after operation. According to the recurrence and metastasis of patients 1 year after surgery, patients were grouped into high-risk and low-risk groups. The value of preoperative DCE-MRI and TMEM51-AS1 in the assessment of postoperative recurrence and metastasis was analyzed using the receiver operating characteristic curve. CCK-8 and Transwell assays were performed to evaluate the influence of TMEM51-AS1 on TNBC cellular capacities. TMEM51-AS1 was decreased in TNBC tissues, especially in high-risk groups. TMEM51-AS1 expression, Max Slope, and Max Cone were risk factors associated with postoperative recurrent metastasis, and combined three had a high diagnostic value in predicting postoperative recurrent metastasis. Increased TMEM51-AS1 weakened TNBC cell proliferation, migration, and invasion by regulating miR-19a-3p. Combined preoperative DCE-MRI and TMEM51-AS1 testing may be used to predict the risk of postoperative recurrent metastasis in patients with TNBC. TMEM51-AS overexpression may repress TNBC progression by miR-19a-3p, which may guide the subsequent clinical management and improve the survival of TNBC patients.
期刊介绍：
The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.
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