Consensus on the research and application of artificial intelligence in coronary computed tomography angiography

Coronary computed tomography angiography (CCTA), which enables noninvasive assessment of luminal stenosis and atherosclerotic plaque components, has become the first-line technique for evaluating coronary artery disease. Artificial intelligence (AI) has the potential to revolutionize the CCTA workflow. However, it is crucial to evaluate the effectiveness and feasibility of AI algorithms before their clinical deployment. This expert consensus proposes three fundamental elements of research designs of AI in CCTA and offers corresponding recommendations. The consensus also reviews the existing evidence on AI applications in CCTA and provides recommendations on the current clinical applications of AI, including image acquisition and reconstruction, postprocessing, diagnosis, prognostic prediction, guiding prevention and treatment, and cardiovascular disease prevention.