{"title":"基于geant4的核极化成像模拟蒙特卡罗算法的开发","authors":"Rasool Safari , Yasaman Aboulghasemi , Reza Faghihi , Mohammadreza Parishan , Zahra Rakeb","doi":"10.1016/j.ejmp.2025.105081","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Polarized Nuclear Imaging (PNI) is a novel gamma imaging approach that encodes spatial information by using polarized radioactive nuclei and manipulating them with magnetic fields, gradients, and RF pulses. The resulting anisotropic photon emission yields direct k-space encoding, removing the need for collimators.</div></div><div><h3>Purpose</h3><div>The work will focus on developing the first, high-performance Monte Carlo-based algorithm for PNI, fully integrated into the GATE framework. Using Monte Carlo simulations, there is an expectation of a strong push in research concerning PNI and a better understanding and use of this new imaging technique.</div></div><div><h3>Methods</h3><div>An algorithm based on Geant4 was implemented and coupled with GATE in the form of a new type of source. This extension allows users to define a PNI source, configure its parameters, and use GATE’s basic functionalities to perform simulation studies in PNI. The source of GATE-based PNI generates photons in directions according to the PNI-encoded method, which maps spatial information into the spin orientations of polarized radioactive nuclei.</div></div><div><h3>Results</h3><div>The tool exhibited extremely small average relative errors (∼0.0000018 %) when replicating theoretical angular distributions of gamma emissions from oriented nuclei, and a 3.57 % difference from theory in extracting k-space data using the detector-based PNI method. A complex PNI source also yielded results consistent with experimental data.</div></div><div><h3>Conclusions</h3><div>This GATE-based PNI simulation toolkit offers an efficient, user-friendly, and accurate method for investigating PNI, paving the way for advanced research and system optimization.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105081"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of a GEANT4-Based Monte Carlo algorithm for polarized nuclear imaging simulations integrated into GATE\",\"authors\":\"Rasool Safari , Yasaman Aboulghasemi , Reza Faghihi , Mohammadreza Parishan , Zahra Rakeb\",\"doi\":\"10.1016/j.ejmp.2025.105081\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Polarized Nuclear Imaging (PNI) is a novel gamma imaging approach that encodes spatial information by using polarized radioactive nuclei and manipulating them with magnetic fields, gradients, and RF pulses. The resulting anisotropic photon emission yields direct k-space encoding, removing the need for collimators.</div></div><div><h3>Purpose</h3><div>The work will focus on developing the first, high-performance Monte Carlo-based algorithm for PNI, fully integrated into the GATE framework. Using Monte Carlo simulations, there is an expectation of a strong push in research concerning PNI and a better understanding and use of this new imaging technique.</div></div><div><h3>Methods</h3><div>An algorithm based on Geant4 was implemented and coupled with GATE in the form of a new type of source. This extension allows users to define a PNI source, configure its parameters, and use GATE’s basic functionalities to perform simulation studies in PNI. The source of GATE-based PNI generates photons in directions according to the PNI-encoded method, which maps spatial information into the spin orientations of polarized radioactive nuclei.</div></div><div><h3>Results</h3><div>The tool exhibited extremely small average relative errors (∼0.0000018 %) when replicating theoretical angular distributions of gamma emissions from oriented nuclei, and a 3.57 % difference from theory in extracting k-space data using the detector-based PNI method. A complex PNI source also yielded results consistent with experimental data.</div></div><div><h3>Conclusions</h3><div>This GATE-based PNI simulation toolkit offers an efficient, user-friendly, and accurate method for investigating PNI, paving the way for advanced research and system optimization.</div></div>\",\"PeriodicalId\":56092,\"journal\":{\"name\":\"Physica Medica-European Journal of Medical Physics\",\"volume\":\"137 \",\"pages\":\"Article 105081\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physica Medica-European Journal of Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1120179725001917\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica Medica-European Journal of Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1120179725001917","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Development of a GEANT4-Based Monte Carlo algorithm for polarized nuclear imaging simulations integrated into GATE
Background
Polarized Nuclear Imaging (PNI) is a novel gamma imaging approach that encodes spatial information by using polarized radioactive nuclei and manipulating them with magnetic fields, gradients, and RF pulses. The resulting anisotropic photon emission yields direct k-space encoding, removing the need for collimators.
Purpose
The work will focus on developing the first, high-performance Monte Carlo-based algorithm for PNI, fully integrated into the GATE framework. Using Monte Carlo simulations, there is an expectation of a strong push in research concerning PNI and a better understanding and use of this new imaging technique.
Methods
An algorithm based on Geant4 was implemented and coupled with GATE in the form of a new type of source. This extension allows users to define a PNI source, configure its parameters, and use GATE’s basic functionalities to perform simulation studies in PNI. The source of GATE-based PNI generates photons in directions according to the PNI-encoded method, which maps spatial information into the spin orientations of polarized radioactive nuclei.
Results
The tool exhibited extremely small average relative errors (∼0.0000018 %) when replicating theoretical angular distributions of gamma emissions from oriented nuclei, and a 3.57 % difference from theory in extracting k-space data using the detector-based PNI method. A complex PNI source also yielded results consistent with experimental data.
Conclusions
This GATE-based PNI simulation toolkit offers an efficient, user-friendly, and accurate method for investigating PNI, paving the way for advanced research and system optimization.
期刊介绍:
Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics:
Medical Imaging
Radiation Therapy
Radiation Protection
Measuring Systems and Signal Processing
Education and training in Medical Physics
Professional issues in Medical Physics.