在计算机上评估在常规和FLASH方案中递送的高能电子用于SBRT治疗胰腺癌的潜力:三个案例研究的报告

IF 2.7 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
A. De Gregorio , A. Muscato , A. Burattini , D. Carlotti , M. Fiore , G. Franciosini , T. Insero , M. Marafini , V. Marè , V. Patera , F. Quattrini , S. Ramella , A. Schiavi , M. Toppi , G. Traini , A. Trigilio , A. Sarti
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引用次数: 0

摘要

背景与目的:随着胰腺癌的发病率和死亡率不断上升,寻找有效的治疗方法变得越来越迫切。在治疗方法中,高度低分割立体定向治疗正在探索中。本文根据紧凑型加速器技术的最新进展及其与超高剂量率(UHDR)传输的兼容性,探讨了80-130 MeV范围内的甚高能电子(VHEE)的潜力。材料和方法:使用剂量-体积直方图和剂量图,我们比较了模拟和优化的VHEE治疗方案,假设传统和UHDR给药方案,以及最先进的体积调制电弧治疗(VMAT)治疗方案,用于治疗三名患者。已经获得了剂量图,假设具有类似imrt的几何形状。所实现的VHEE束流模型采用c波段紧凑加速技术。结果表明,低于130 MeV的电子即使在常规条件下传递,也具有明显的有效治疗胰腺癌的潜力。已经探索了超高辐射辐射的递送,评估了闪射效应在对PTV的剂量递增方面可能提供的增益,同时限制了对十二指肠的最大允许生物剂量。结论:所获得的结果表明VHEE在胰腺癌治疗中的适用性,即使不考虑FLASH效应的额外节省,其优化方案在临床上也是可接受的。它们适合于以FLASH速率传递,这使它们成为未来外部放射治疗的极好候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In silico evaluation of the potential of very high energy electrons delivered in both conventional and FLASH regimes for the SBRT treatment of pancreatic cancer: A report of three case studies

Background and purpose:

As the incidence and mortality rates of pancreatic cancer continue to rise, the search for effective treatments is becoming increasingly urgent. Among the therapeutic approaches, highly hypofractionated stereotactic treatments are being explored. This paper explores the potential of Very High Energy Electrons (VHEE) in the range of 80-130 MeV, in light of recent advances in compact accelerator technology and its compatibility with ultra-high dose rate (UHDR) delivery.

Materials and methods:

Using dose-volume histograms and dose maps, we compared VHEE treatment plans simulated and optimized assuming both conventional and UHDR delivery scenarios against state-of-the-art volumetric modulated arc therapy (VMAT) treatment plans that were used to treat three patients. Dose maps have been obtained assuming an IMRT-like geometry. The implemented VHEE beam model assumes a C-band compact accelerating technology. Results show that electrons below 130 MeV have a clear potential for the effective treatment of pancreatic cancer, even if delivered in conventional conditions. UHDR delivery has been explored evaluating the gain that the FLASH effect could provide in terms of dose escalation to the PTV while constraining the maximum allowed biological dose to the duodenum.

Conclusion:

The obtained results demonstrate the suitability of VHEE for pancreatic cancer treatment with optimized plans that are clinically acceptable even without considering the additional sparing from the FLASH effect. Their suitability for being delivered at FLASH rates makes them an excellent candidate for the future of external beam radiotherapy.
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来源期刊
CiteScore
6.80
自引率
14.70%
发文量
493
审稿时长
78 days
期刊介绍: Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.
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