A. De Gregorio , A. Muscato , A. Burattini , D. Carlotti , M. Fiore , G. Franciosini , T. Insero , M. Marafini , V. Marè , V. Patera , F. Quattrini , S. Ramella , A. Schiavi , M. Toppi , G. Traini , A. Trigilio , A. Sarti
{"title":"在计算机上评估在常规和FLASH方案中递送的高能电子用于SBRT治疗胰腺癌的潜力:三个案例研究的报告","authors":"A. De Gregorio , A. Muscato , A. Burattini , D. Carlotti , M. Fiore , G. Franciosini , T. Insero , M. Marafini , V. Marè , V. Patera , F. Quattrini , S. Ramella , A. Schiavi , M. Toppi , G. Traini , A. Trigilio , A. Sarti","doi":"10.1016/j.ejmp.2025.105076","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose:</h3><div>As the incidence and mortality rates of pancreatic cancer continue to rise, the search for effective treatments is becoming increasingly urgent. Among the therapeutic approaches, highly hypofractionated stereotactic treatments are being explored. This paper explores the potential of Very High Energy Electrons (VHEE) in the range of 80-130 MeV, in light of recent advances in compact accelerator technology and its compatibility with ultra-high dose rate (UHDR) delivery.</div></div><div><h3>Materials and methods:</h3><div>Using dose-volume histograms and dose maps, we compared VHEE treatment plans simulated and optimized assuming both conventional and UHDR delivery scenarios against state-of-the-art volumetric modulated arc therapy (VMAT) treatment plans that were used to treat three patients. Dose maps have been obtained assuming an IMRT-like geometry. The implemented VHEE beam model assumes a C-band compact accelerating technology. Results show that electrons below 130 MeV have a clear potential for the effective treatment of pancreatic cancer, even if delivered in conventional conditions. UHDR delivery has been explored evaluating the gain that the FLASH effect could provide in terms of dose escalation to the PTV while constraining the maximum allowed biological dose to the duodenum.</div></div><div><h3>Conclusion:</h3><div>The obtained results demonstrate the suitability of VHEE for pancreatic cancer treatment with optimized plans that are clinically acceptable even without considering the additional sparing from the FLASH effect. Their suitability for being delivered at FLASH rates makes them an excellent candidate for the future of external beam radiotherapy.</div></div>","PeriodicalId":56092,"journal":{"name":"Physica Medica-European Journal of Medical Physics","volume":"137 ","pages":"Article 105076"},"PeriodicalIF":2.7000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In silico evaluation of the potential of very high energy electrons delivered in both conventional and FLASH regimes for the SBRT treatment of pancreatic cancer: A report of three case studies\",\"authors\":\"A. De Gregorio , A. Muscato , A. Burattini , D. Carlotti , M. Fiore , G. Franciosini , T. Insero , M. Marafini , V. Marè , V. Patera , F. Quattrini , S. Ramella , A. Schiavi , M. Toppi , G. Traini , A. Trigilio , A. Sarti\",\"doi\":\"10.1016/j.ejmp.2025.105076\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and purpose:</h3><div>As the incidence and mortality rates of pancreatic cancer continue to rise, the search for effective treatments is becoming increasingly urgent. Among the therapeutic approaches, highly hypofractionated stereotactic treatments are being explored. This paper explores the potential of Very High Energy Electrons (VHEE) in the range of 80-130 MeV, in light of recent advances in compact accelerator technology and its compatibility with ultra-high dose rate (UHDR) delivery.</div></div><div><h3>Materials and methods:</h3><div>Using dose-volume histograms and dose maps, we compared VHEE treatment plans simulated and optimized assuming both conventional and UHDR delivery scenarios against state-of-the-art volumetric modulated arc therapy (VMAT) treatment plans that were used to treat three patients. Dose maps have been obtained assuming an IMRT-like geometry. The implemented VHEE beam model assumes a C-band compact accelerating technology. Results show that electrons below 130 MeV have a clear potential for the effective treatment of pancreatic cancer, even if delivered in conventional conditions. UHDR delivery has been explored evaluating the gain that the FLASH effect could provide in terms of dose escalation to the PTV while constraining the maximum allowed biological dose to the duodenum.</div></div><div><h3>Conclusion:</h3><div>The obtained results demonstrate the suitability of VHEE for pancreatic cancer treatment with optimized plans that are clinically acceptable even without considering the additional sparing from the FLASH effect. Their suitability for being delivered at FLASH rates makes them an excellent candidate for the future of external beam radiotherapy.</div></div>\",\"PeriodicalId\":56092,\"journal\":{\"name\":\"Physica Medica-European Journal of Medical Physics\",\"volume\":\"137 \",\"pages\":\"Article 105076\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physica Medica-European Journal of Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1120179725001863\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physica Medica-European Journal of Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1120179725001863","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
In silico evaluation of the potential of very high energy electrons delivered in both conventional and FLASH regimes for the SBRT treatment of pancreatic cancer: A report of three case studies
Background and purpose:
As the incidence and mortality rates of pancreatic cancer continue to rise, the search for effective treatments is becoming increasingly urgent. Among the therapeutic approaches, highly hypofractionated stereotactic treatments are being explored. This paper explores the potential of Very High Energy Electrons (VHEE) in the range of 80-130 MeV, in light of recent advances in compact accelerator technology and its compatibility with ultra-high dose rate (UHDR) delivery.
Materials and methods:
Using dose-volume histograms and dose maps, we compared VHEE treatment plans simulated and optimized assuming both conventional and UHDR delivery scenarios against state-of-the-art volumetric modulated arc therapy (VMAT) treatment plans that were used to treat three patients. Dose maps have been obtained assuming an IMRT-like geometry. The implemented VHEE beam model assumes a C-band compact accelerating technology. Results show that electrons below 130 MeV have a clear potential for the effective treatment of pancreatic cancer, even if delivered in conventional conditions. UHDR delivery has been explored evaluating the gain that the FLASH effect could provide in terms of dose escalation to the PTV while constraining the maximum allowed biological dose to the duodenum.
Conclusion:
The obtained results demonstrate the suitability of VHEE for pancreatic cancer treatment with optimized plans that are clinically acceptable even without considering the additional sparing from the FLASH effect. Their suitability for being delivered at FLASH rates makes them an excellent candidate for the future of external beam radiotherapy.
期刊介绍:
Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics:
Medical Imaging
Radiation Therapy
Radiation Protection
Measuring Systems and Signal Processing
Education and training in Medical Physics
Professional issues in Medical Physics.